可降解镁合金临床应用的最新研究进展-中国材料进展

文章信息/Info

Title:: Latest Research Progress of Biodegradable Magnesium Alloys in Clinical Applications

Author(s):: YIN Lin; HUANG Hua; YUAN Guangyin; DING Wenjiang; National Engineering Research Center of Light Alloy Net Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China

Keywords:: biodegradable magnesium alloys; bone implants; cardiovascular stents; biocompatibility; clinical application

摘要:: 作为新一代可降解医用金属材料，镁合金具有良好的力学性能、生物可降解性以及生物相容性。镁合金用作骨修复材料时，可以有效避免应力遮挡效应，有利于促进骨愈合；用作血管支架材料时，可以在狭窄的血管内经过一段时间支架支撑和药物治疗完成正性重构后，自行降解消失，从而降低再狭窄的风险。因此镁合金作为可降解医用材料具有很广阔的临床应用前景，在骨内植物器械和血管支架等领域有巨大的应用潜力。首先介绍了镁合金作为可降解医用材料所具有的优点以及目前所面临的主要挑战，然后分别阐述了镁合金在骨内植物器械和血管支架领域临床应用研究的最新进展，重点介绍了上海交通大学有关可降解医用镁合金的最新进展，最后总结并展望了可降解医用镁合金未来的发展前景。

Abstract:: Magnesium (Mg) alloys have excellent properties such as good mechanical property, biodegradation and biocompatibility, as a new generation of biodegradable metal materials. Mg alloys can avoid the stress shielding effect and promote the healing of bone for bone implants application. Mg alloys can also reduce the risk of restenosis by selfdegradation after a period of positive remodeling with stent support and drug treatment in the stenosis vessels for cardiovascular stent application. Therefore, Mg alloys have broad prospects for these applications. In this paper, the advantages and major challenges of Mg alloys as biodegradable materials are introduced firstly. Then, the latest research progress of biodegradable magnesium alloys in bone implants and stent applications are introduced respectively, with emphasis on the latest development of biodegradable medical magnesium alloys in Shanghai Jiao Tong University. Finally, the clinical application prospects of the biodegradable Mg alloys are discussed.