智能水凝胶及其在生物方向的应用-中国材料进展

文章信息/Info

Author(s):: LIU Cheng; QIAO Liyuan; LIU Chengde; YANG Liquan; JIAN Xigao; (Department of Polymer Materials, College of Chemical Engineering, Dalian University of Technology, Dalian 116024, China)

Keywords:: temperature sensitivity; pH responsiveness; selfhealing property; drug delivery; cell loading and delivery; wound dressing

摘要:: 水凝胶含水量极高、质地柔软且具有优异的生物相容性。其中，智能水凝胶因其优异的环境响应性而备受关注。近年来，各类智能水凝胶层出不穷，其机械强度从数十帕变化到数十兆帕，在生物医学领域的应用包括药物载体、组织工程支架等。基于此，详细总结了近年来智能水凝胶的发展及应用。首先，依据不同的分类方式对水凝胶进行了分类。进一步，重点对智能水凝胶进行了详细的分类，包括温敏性水凝胶、pH响应性水凝胶、自修复水凝胶等，同时对每类智能水凝胶的制备及应用进行了详细的介绍。最后，概述了智能水凝胶在生物方向的应用，包括药物载体、细胞负载与传递、伤口敷料等。

Abstract:: Hydrogels, with high water content, have soft texture and excellent biocompatibility. Among them, intelligent hydrogels have attracted much attention due to their excellent environmental responsiveness. The intelligent hydrogels emerge in endlessly in recent years, the mechanical strength of intelligent hydrogels changes from tens of Pa to tens of MPa, and they can be applied in biomedicine including drug carriers, tissue engineering scaffolds, etc. Based on this, this paper summarizes the development and applications of intelligent hydrogels in recent years. Firstly, hydrogels can be classified into different types according to different classification methods. Furthermore, this paper mainly summarizes different types of intelligent hydrogels, including temperature sensitive hydrogels, pH responsive hydrogels and self-healing hydrogels, also elaborates and analyzes the experimental cases of each kind of intelligent hydrogels in detail. Finally, the applications of various intelligent hydrogels in biological fields are summarized, including drug delivery, cell loading and delivery, wound dressing, etc.