[1]覃丽婷,孙芸,徐柏龙,等.MOFs衍生纳米酶在肿瘤治疗中的研究进展[J].中国材料进展,2022,41(09):706-717.[doi:10.7502/j.issn.1674-3962.202208005]
 QIN Liting,SUN Yun,XU Bolong,et al.Research Progress of MOFs-Derived Nanozymes in Tumor Therapy[J].MATERIALS CHINA,2022,41(09):706-717.[doi:10.7502/j.issn.1674-3962.202208005]
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MOFs衍生纳米酶在肿瘤治疗中的研究进展()
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中国材料进展[ISSN:1674-3962/CN:61-1473/TG]

卷:
41
期数:
2022年第09期
页码:
706-717
栏目:
出版日期:
2022-09-30

文章信息/Info

Title:
Research Progress of MOFs-Derived Nanozymes in Tumor Therapy
文章编号:
1674-3962(2022)09-0706-12
作者:
覃丽婷孙芸徐柏龙刘惠玉
(北京化工大学 有机无机复合材料国家重点实验室,北京 100029)
Author(s):
QIN LitingSUN YunXU BolongLIU Huiyu
(Key Laboratory of OrganicInorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China)
关键词:
金属有机框架纳米酶活性调控催化疗法肿瘤治疗
Keywords:
metal organic framework nanozyme activity regulation catalytic therapy tumor therapy
分类号:
TB383.1;R318.08; R730.4
DOI:
10.7502/j.issn.1674-3962.202208005
文献标志码:
A
摘要:
纳米酶是具有类酶活性的纳米材料,与天然酶相比,纳米酶具有易于合成、活性可调和高稳定性的优势。金属有机框架(metal-organic frameworks,MOFs)衍生纳米酶作为纳米酶家族的新成员,因其丰富的活性位点和可控的催化活性,吸引了研究者的广泛关注。与传统纳米酶相比,MOFs衍生纳米酶保留了MOFs的多孔结构,同时表现出良好的生物相容性和高催化活性,在包括肿瘤催化治疗在内的生物医学应用中展现出广阔的前景。系统地总结了MOFs衍生纳米酶的种类,包括MOFs衍生的金属氧化物、金属/碳、金属氧化物/碳、金属硫化物以及单原子纳米酶。此外,重点讨论了MOFs衍生纳米酶的活性调控策略,如表面结构调控、杂原子掺杂、双金属构建和基于MOFs的配体交换策略。同时,回顾了近年来MOFs衍生纳米酶介导的催化治疗及其联合其他疗法在抗肿瘤领域的应用。最后,总结了MOFs衍生纳米酶目前在生物医学领域中面临的挑战和前景,以期推动MOFs衍生纳米酶的开发并拓展其进一步的生物医学应用转化。
Abstract:
Nanozymes are a class of nanomaterials with enzyme-like activity. Compared with natural enzymes, nanozymes have the advantages of easy synthesis, adjustable activity, and high stability. The nanozymes derived from the metal-organic frameworks (MOFs), as a new family member of nanozymes, have attracted widespread attention due to their rich active sites and controllable catalytic activity. Compared with the traditional nanozymes, MOFs-derived nanozymes maintain the porous structure of MOFs, as well as possess good biocompatibility and high catalytic activity, showing a broad prospect in the biomedical field including tumor catalytic therapy. In this review, we systematically summarize the classification of MOFs-derived nanozymes, including MOFs-derived metal oxides, metal/carbon, metal oxides/carbon, metal sulfide, and single-atom nanozymes (SAzymes). In addition, we also focus on the activity regulation strategies of MOFs-derived nanozymes, such as surface structure regulation, heteroatomic doping, bimetallic construction, and MOFs-based linker exchange strategy. Furthermore, we review the applications of catalytic therapies based on MOFs-derived nanozymes and their synergistic therapies in recent years. Finally, we propose the challenges and prospects of MOFs-derived nanozymes in the biomedical field, to promote the development of MOFs-derived nanozymes and expand their further biomedical application transformation.

备注/Memo

备注/Memo:
收稿日期:2022-08-09 修回日期:2022-09-08 基金项目:科技部重点研发计划项目(2021YFC2102900);国家自然科学基金项目(U21A2085);国际(地区)合作研究与交流项目(22061130205);北京化工大学中日友好医院生物医学转化工程研究中心联合项目(XK2022-08);北京化工大学有机无机复合材料国家重点实验室开放基金项目(OIC-202201010)第一作者:覃丽婷,女,1996年生,硕士研究生孙芸,女,1995年生,博士研究生,通讯作者:刘惠玉,女,1978年生,教授,博士生导师, Email:liuhy@mail.buct.edu.cn
更新日期/Last Update: 2022-08-22