(National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China)
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DOI:
10.7502/j.issn.1674-3962.2012.05.03
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Abstract:
Peptide dendrimers are attractive synthetic polymers which have been widely used as a new generation of biomaterials. Peptide dendrimers can be prepared via organic synthesis, showing nano sizes, and display well defined architectures, highly branched structures, high density of functional terminal groups, and controllable molecular weights. Peptide dendrimers have received considerable attention in biomedicine due to their properties similar to proteins and some special characteristics, such as good biocompatibility, water solubility and resistance to proteolytic digestion. In this paper, we review the synthesis of peptide dendrimers and their applications in diagnostics as well as therapy.