College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
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DOI:
10.7502/j.issn.1674-3962.2014.11.03
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Abstract:
The distinctive features of nanofibers (such as huge surface area to volume ratio, controllable porous secondary structure, etc) enable them to be widely used in the fields of environmental protection, energy, catalysts, drug delivery, and tissue engineering scaffolds. Nanofibers prepared by electrospinning technology mainly include organic nanofibers, inorganic nanofibers, and inorganic/organic hybrid nanofibers. In this review, based on our previous work associated with electrospun hybrid nanofiber systems, the construction of various drug-loaded electrospun organic/inorganic hybrid nanofibers for biomedical applications has been reviewed. In particular, this review mainly introduces the loading of drug molecules onto or within various inorganic nanoparticles (e. g. , halloysite nanotubes, laponite nanodisks, nanohydroxyapatite, mesoporous silica, etc.) for subsequent electrospinning with polymers to form electrospun hybrid nanofiber-based double drug carrier systems, and the associated mechanisms related to the sustained release of the encapsulated drug molecules. The biomedical applications of the drug-loaded hybrid electrospun nanofibers, especially in antibacterial and antitumor therapy applications have been also reviewed. The review ends with a brief outlook of some of the future aspects of this area of research.