Many animals (gecko, beetle, tree frog, etc.) can climb on various substrates by reversible adhesion forces, which are determined by the micro/nano-pillar structures (seta, smooth pad, etc.) on their toe pads. The mirco/nano-pillars with fine sub-structures ensure numerous effective contact points between the toe pad and the substrate, forming tremendous adhesion forces as high as 200 folds of animal’s body weight. On the other hand, the fine structures in mirco/nano-pillars also ensure the effective detachment from the adhering surface. The adhesion abilities, relying on the fine structures rather than the surface chemistry, arise great scientific interests and wide potential applications.