1.The Second School of Clinical Medicine of Xinjiang Medical University, Urumqi 830054, China
2.School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830054, China
3. Institute of Public Health, Xinjiang Medical University, Urumqi 830054, China
et al.
With the advantages of strong near-infrared (NIR, 760~1700 nm) fluorescence emission, good biocompatibility, high photothermal conversion efficiency and good stability, the new indocyanine green IR-820 has stood out among the existing organic NIR fluorescent dyes and has been widely used in the research fields of biomedical imaging, fluorescent labeling, real-time cell monitoring and photothermal therapy. Researchers have modified IR-820 with different biochemical molecules to enhance its fluorescence and photothermal properties, multiple types of IR-820 fluorescent nanoparticles have been prepared and investigated in biomedical imaging and tumor photothermal therapy. This article has summarized the applications of the synthesized IR-820 nanoparticles in near-infrared fluorescence (NIRF) imaging and tumor photothermal therapy and synergistic therapy, aiming to provide a reference for the further development of NIR organic fluorescent dye IR-820 in the biomedical field and the further clinical translation.