Ni-base crystalline superalloy has excellent creep resistance, and is widely used in aerospace engineering, energy and power generation and other industrial fields. With the development of industry technology, the requirements for creep properties of Ni-base crystalline superalloy have become more and more stringent. Researchers have carried out a lot of work, focusing on the effect of alloying elements on the creep properties, in order to achieve maximum creep resistance improvement by adding alloying elements. The effect of alloying elements on carbide phase, grain boundary, γ matrix phase and γ′ precipitation phase is reviewed in this paper, providing some scientific guidance for the design, preparation and creep properties improvement of Ni-base crystalline superalloys in the future.