State Key Laboratory of Medicinal Chemical Biology, College of Life Science, Nankai University, Tianjin 200071, China
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DOI:
10.7502/j.issn.1674-3962.2015.03.03
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Abstract:
The construction of 3D biological substitutes consisting of cells and scaffolds is an expected approach for tissue and organ restoration. Normal biological activities of cells requires the continuous stimulation of signaling molecules from the extracellular microenvironment. As an important part of the artificial extracellular matrix, both chemical signals and physical forces of the biomaterials remodeling regulate cell gene and protein express but far not enough to sculpt tissue structure. Using gene and protein engineering technology, a fusion protein could be designed with multiple functions and improved the biological activities of natural or synthetic materials. In this article, we summarize the developments of biomaterials based on the fusion protein, as well as the concepts of fusion protein design and preparation. Meanwhile, we highlight the applications of fusion proteins that related to cell growth factors and cell adhesion factors in tissue engineering.