Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences
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DOI:
10.7502/j.issn.1674-3962.2015.07.12
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Abstract:
Due to their similarities to bio-tissues, and excellent biocompatibility and biosafety, polymer hydrogels have been widely studied for potential applications in tissue engineering, drug delivery, and wound dressing, etc. The development of tough and responsive hydrogels has recently been a very hot topic with great challenges. In this review, progresses in the development of novel hydrogels including nanocomposite hydrogels, double network hydrogels and responsive hydrogels in last decade are reviewed. Several imporant design philosophy and synthesis method are accounted. The toughening mechanisms and energy dissipation mechanisms of a few representative strong and tough polymer hydrogels are introduced. Moreover, some smart and stimuli-responsive hydrogels based on cationic, anionic, and zwitteronic monomers are reviewed and discussed in detail. Based on these progresses, the major challenges of strong, tough, and responsive hydrogels as biomaterials are analyzed. Finally, the perspectives of tough and responsive hydrogels were discussed.