Abstract

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Author(s):: SONG Juqing 1; 2; SHI Xuetao 1; 2; WANG Yingjun 1; 2; (1.National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology,
(2.School of Materials Science and Engineering, South China University of Technology

Abstract:: Always, the clinical therapy of criticalsized bone defects caused by trauma, tumor removal surgery and congenital malformation undergoes great challenges. The traditional treatments for bone defects, including autografting, are unable to meet the clinical needs because of the shortage of donors and immunological rejection. The development of tissue engineering changes the traditional treatment modes, and various tissue engineering cellbiomaterial composite scaffolds based on synthetic and natural biomaterials have been implemented to reconstruct injured bone. At the same time, more researchers aware the important role of periosteum in the bone defect healing, especially the integration and vascularization of the scaffold materials. Except the periosteum grafts (autoor allo), researchers also provide a biomimetic methodology that integrates the concept of tissue engineering into the periosteum repair. A variety of periosteum tissue engineering have been proposed, which biomimic the native periosteum from structure or function. Here we simply review four types of functional tissue engineering periosteum, including structure biomimic, microstructure biomimic, vascularization and mechanical stimulation, which would provide theoretical basis and open new opportunities for the construction of bone tissue engineering and the research of periosteum.