Ti2AlNb alloy with orthorhombic phase represents the youngest class of alloys emerging out of Ti-Al titanium aluminides, as a constituent in Ti3Al-based alloy. With excellent high temperature performance and lower density, this new material is aimed to replace the existing Inconel 718 nickel-based superalloy, used in the manufacture of high thrust weight ratio aeroengine non-rotating parts or even rotating parts. This article briefly summarized the characteristics of Ti2AlNb alloy and the main progress made in the engineering technologies of Ti2AlNb alloy in China in recent years. In addition, the existing shortcomings of Ti2AlNb alloy and the main problems in the current research were also discussed. It was pointed out that the industrial production process technology with lower cost and higher production efficiency should be developed basing on the existing titanium alloy smelting and processing equipment and combining with the characteristics of Ti2AlNb alloy.