(1. School of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China) (2. High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China)
Bioglass was firstly invented to regenerate bone, in recent years it has also been applied in the regeneration of cartilage and soft tissues, such as skin, cornea, lung and nerve. The representative bioglass includes silicate bioglass and borate bioglass, they release abundant ions in physiological environment and induce specific biological responses, such as antibacterial effect, promoting cell adhesion, proliferation, migration and angiogenesis. Doping elements are crucial for the properties of bioglass, which perform different effects in tissue healing. What’s more, the structure of bioglass is also important for cell growth and tissue repair. Due to the adverse properties of bioglass, such as low toughness and high fragility, it is usually compounded with metals，polymers as composite materials to be applied in tissue repair. In this paper, the relationship between physical and chemical properties of bioglass and its bioactivity is reviewed, the recent application progress of composite materials derived from bioglass is introduced and discussed, which will provide reference for the advanced medical materials in the field of tissue regeneration.