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Research Progress of Structural Modification of Drug Carrier to Achieve Endosome Escape(PDF)

MATERIALS CHINA[ISSN:1674-3962/CN:61-1473/TG]

Issue:
2019年第03期
Page:
271-278
Research Field:
前沿综述
Publishing date:

Info

Title:
Research Progress of Structural Modification of Drug Carrier to Achieve Endosome Escape
Author(s):
LI Chenglong1LI Rongye1YUN Peng1ZHANG Guanhong2XI Laishun1WANG Yuandou1SU Feng1
(1.College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China)(2.Shengli Oilfield Central Hospital, Dongying 257000, China)
Keywords:
drug carriers endosome escape protonation photochemical internalization structural modification
CLC:

PACS:
-
DOI:
10.7502/j.issn.1674-3962.2019.03.09
DocumentCode:

Abstract:
Nanocarriers have been widely used for drug delivery because of their good biocompatibility, tissue permeability, nontoxicity, and easy absorption. The drug carrier enters the target site by cell endocytosis. During this process, the barrier function of the endosome is an important factor limiting the efficiency of drugs. This paper starts from the mechanism of endosome escape. The escape agents realize the endosomal escape by means of protonation effects, membrane fusing or membrane pore forming, membrane destructing, and immunity shielding. The modification of the carrier material by using the escape agents like polymer materials, peptides, photochemical reagents, and pHsensitive materials to achieve the escape are reviewed. Finally, the future development of the escape of the endosome is prospected.

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Last Update: 2019-04-03