1. Jiangsu Key Laboratory for Biomaterials and Devices, State Key Laboratory of Bioeletronics, School of Biological Sciences & Medical Engineering, Southeast University 2. Clinical Medical Engineering Office, Nanjing Drum Tower Hospital of Nanjing University Medical School 3. Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital of Nanjing University Medical School 4. Collaborative Innovation Center of Suzhou Nano-Science and Technology
Stem cell therapy is the most promising treatment in the field of tissue repair. However, vast majority of current investigations still remain in the stage of laboratory. It is of great significance to detect the distribution, activity, differentiation and apoptosis of stem cells after transplantation by in-vivo tracing technique. Therefore, the development of the techniques for tracing stem cells has played a crucial role in solving these problems. Nowadays, magnetic resonance imaging (MRI) has been used to explore long-term in-vitro tracing of magnetic nanoparticles labeled stem cells. Furthermore, it is noninvasive, real-time, safe and effective. The principle of mesenchymal stem cells (MSCs) for tissue repair was systematically summarized. Also, the labeling and assistance effect of magnetic nanoparticles on MSCs for tissue repair were reviewed.