Liquid silicone rubber has good chemical stability and biocompatibility and is widely used in medical and medical equipment fields. However, in practical applications, there are several shortcomings, such as insufficient mechanical support strength, insufficient stability, and easy to cause infection.Therefore,improving the mechanical strength, antibacterial properties,chemical stability and biological activity of liquid silicone rubber is the primary problem to be solved. It was found that adding various nanofillers to the liquid silicone rubber matrix can not only improve the mechanical properties, but also improve the electrical and antibacterial properties to a better level. This paper briefly summarizes the classification, construction and performance improvement methods of liquid silicone rubber, and focuses on the current research status and bottleneck problems in the application of liquid silicone rubber in the medical field. The research progress of biomedical functional modification of liquid silicone is expected to improve the dispersion of nanomaterials in liquid silicone and improve its antibacterial, mechanical and stability, enhance the application value of liquid silicone rubber and expand its application scenarios.