(1.Jiangsu Key Laboratory of Molecular and Functional Imaging, School of Medicine, Southeast University, Nanjing 210009, China) (2.Jiangsu Key Laboratory of Biomaterials and Devices, State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210009, China)
Iron-based magnetic nanomaterials can transform magnetic field into local energy such as thermal, electrical and mechanical stimulation. With the assistance of the magnetic nanoparticles, precise remote wireless regulation of neurons can be realized by applying external magnetic field, which provides a good application prospect in both of the basic research of neuroscience and the clinical treatment of nerve diseases. This paper reviewed the application of the magnetic nanoparticles in magnetogenetics, magnetothermal genetics, magnetoelectric effect, magnetic field induced mechanical force and chemomagnetic neural regulations. The stable duration and in vivo biosafety of the implanted nanomaterials，as well as the interaction between the nanomaterilas and cell membrane were discussed. At last, the future development of the iron-based magnetic nanomaterials in neural regulation was prospected.