Hepatic malignancies represent a formidable global health threat. While transarterial chemoembolization (TACE) has emerged as the gold standard therapy for patients with intermediate-to-advanced stage hepatic malignancies, its efficacy is frequently compromised by hypoxia-induced drug resistance and high postoperative recurrence rate. Magnetic hyperthermia microspheres (MHMs), as a novel interventional modality integrating physical embolization with magnetic hyperthermia therapy (MHT), achieve precise tumor intervention by converting magnetic energy into thermal energy under an alternating magnetic field (AMF).This review systematically summarizes the diverse fabrication techniques for MHMs, such as photopolymerization and microfluidics, and discusses their heat-generation mechanisms alongside critical evaluation metrics, including specific absorption rate (SAR) and intrinsic loss power (ILP). Furthermore, we highlight the synergistic strategies of MHMs in combination with TACE, transarterial radioembolization (TARE) and immunotherapy. Emphasis is placed on their immense potential to overcome hypoxiadriven resistance, enhance radiosensitivity and induce immunogenic cell death (ICD) to remodel the tumor microenvironment (effectively converting “cold” tumors into “hot” ones). Despite significant preclinical advancements,challenges remain regarding precise thermometry, long-term biosafety, equipment miniaturization, and the establishment of industry standards. Future research should focus on the development of integrated theranostic systems and personalized therapeutic protocols to accelerate the clinical translation of MHMs.