智能响应型聚合物微粒及其与细胞的相互作用-中国材料进展

文章信息/Info

Title:: Intelligent Responsive Polymeric Particles and Their Interactions with Cells

Author(s):: ZHANG Wenjing; GAO Changyou; （MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China)

摘要:: 智能响应型材料能够感受来自外界的刺激，导致某些物理或者化学性能发生显著的变化，因而有着广泛的研究和应用，尤其是在生物医用材料领域。除传统的温度、光、pH、磁响应方式以外，主要综述了几种生物信号响应型材料，例如生物分子、酶、葡萄糖，以及多重响应型材料；着重介绍用作基因或药物载体的材料。关注不同响应方式的智能材料与细胞之间的相互作用，包括智能响应型微粒的胞吞、胞内转运、细胞内的分布以及响应，和微粒的响应性变化过程比如体积的膨胀收缩，而非材料本身性质与细胞的相互作用。这些结果有利于在细胞和亚细胞层次上理解响应性材料在基因和药物控释中的生物相容性等问题，从而更好地设计载体材料。

Abstract:: Intelligent responsive materials exhibit abrupt changes of physical and/or chemical properties in response to external stimuli. This kind of materials is of great importance in both basic researches and applications, especially in the field of biomedical materials. Besides the traditional photo, pH, magneticresponsive materials, this article briefly summarizes materials responding to several types of biological signals including enzymes, glucose and other biomolecules. The materials with multiresponsive properties are emphasized with respect to the applications for gene and drug delivery. New breakthroughs are introduced on the interactions between the intelligent materials and cells, such as cellular uptake, intracellular transportation and distribution as well as responsivity. The importance of specific stimuliresponsivity such as volume expansion and contraction is envisaged in terms of cellsparticles interaction. This would be intriguing to understand the biocompatibility and some other issues of the stimuliresponsive particles, which in turn can guide the design of delivery carriers of better biological performance.