纳米金属有机框架作为生物成像剂的研究进展-中国材料进展

文章信息/Info

Title:: Recent Advances of Nano Metal-Organic Frameworks as Bio-Imaging Agents

作者:: 祁赵蕊1; 李旭蕊1; 韩莎莎1; 刘宇1; 2; 刘冰弥1; 2; 李丽1; 2; （1.辽宁大学药学院，辽宁沈阳 110036）（2.辽宁大学司法鉴定中心，辽宁沈阳 110036）

Author(s):: QI Zhaorui1; LI Xurui1; HAN Shasha1; LIU Yu1; 2; LIU Bingmi1; 2; LI Li1; 2; (1. School of Pharmacy, Liaoning University, Shenyang 110036, China) (2.Judicial Expertise Center, Liaoning University, Shenyang 110036, China)

Keywords:: metal-organic frameworks; bio-imaging agents; single-modal imaging; dual-modal imaging; tri-modal imaging

摘要:: 金属有机框架材料(metal-organic frameworks, MOFs)由金属离子和有机连接物通过配位化学组装而成，具有不同于传统无机材料的分子性质、功能多样性以及结构和组成的可调性。与其他纳米材料不同，作为一种新型的多孔晶体材料，纳米尺度的MOFs(nano-MOFs, NMOFs)不仅保持了MOFs的结构多样性和物理化学特性，而且颗粒尺寸在几十到数百纳米范围，使NMOFs在气体吸附与分离、催化、磁性、传感以及生物医药等不同领域表现出了优异的性能。由于NMOFs具有比表面积大、孔隙率高、内部孔道尺寸可调和表面可功能化等特性，其作为生物成像剂目前受到越来越多的关注。查阅了近15年来 NMOFs及其复合材料在成像方面应用的文献，总结了NMOFs作为生物成像剂，包括在单成像技术以及复合成像技术中的研究进展，为后续研究人员提供参考。

Abstract:: Metal-organic frameworks (MOFs) are composed of metal ions and organic linkers through coordination chemistry. Their molecular properties, functional diversity and adjustable structure and composition are different from the traditional inorganic material. Different from other nanomaterials, as a new type of porous crystal materials, nano-MOFs(NMOFs) not only maintains the structural diversity and properties of MOFs both in physics and chemistry, but also shows particle sizes ranging from tens to hundreds of nanometers. These advantages make NMOFs exhibit excellent performance in gas adsorption and separation, catalysis, magnetism, sensing, biomedical application, etc. Because NMOFs have the characteristics of large specific surface area, high porosity, adjustable internal pore size and functionalized surface, they have attracted more and more attention as biological imaging agents. In this paper, we reviewed the literature of NMOFs and their composites for imaging in the past 15 years, and summarized the research progress of NMOFs as biological imaging agents, including single imaging technology and composite imaging technology, providing the basis for the subsequent researchers.