MXene基医学材料的材料医学应用-中国材料进展

文章信息/Info

Author(s):: CHEN Liang; FENG Wei; CHEN Yu; (Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai 200444, China)

Keywords:: MXene; synthetic methods; materdicine; biological effect; medicine materials

摘要:: 近年来，二维过渡金属碳化物、氮化物或碳氮化物（MXene），一般化学式为Mn+1XnTx，作为一种新型低维纳米材料在各个领域显示出巨大应用潜力，备受关注。MXene独特的层状结构以及电、光、磁、机械和生物学特性使其成为一种具有广阔应用前景的医学材料。概述了MXene基医学材料的制备方法、设计策略、理化性能、生物效应，尤其是在纳米-生物界面上MXene性能-活性-效应的关系，以及其在生物传感器、抗菌、生物成像、肿瘤治疗、组织工程和再生医学等材料医学领域的应用。最后，深入探讨了MXene基医学材料在材料医学领域目前所面临的挑战和未来发展机遇，旨在推进MXene医学材料在材料医学领域的应用与转化。

Abstract:: Recently, two-dimensional (2D) transition metal carbides, nitrides and carbonitrides, termed as MXene, with a common formula of Mn+1XnTx, have attracted great interest, showing remarkable potential in different research fields. The unique sheet-like structure gifted with specific physical properties including electronic, optical, magnetic and mechanical properties as well as biological characteristics endow MXene a promising medical material for various materdicine applications. In this review, the current state-of-the-art progress of MXene-related medical materials are briefly introduced, especially focusing on the fabrication methods, design strategies, physicochemical properties, biological effects, and particularly the property-activity-effect relationship of MXene at the nano-bio interface. Furthermore, the elaborated MXene for diverse materdicine applications, such as biosensors, antibacteria, bio-imaging, therapeutics, tissue engineering and regenerative medicine, are illustrated in detail. Finally, we discuss the current challenge and opportunities for future development of MXene-based medical materials, aiming to promote their practical applications.