新吲哚菁绿IR-820辅助的近红外荧光成像和光热及协同治疗在肿瘤诊疗中的应用进展-中国材料进展

文章信息/Info

Title:: Recent Advance on New Indocyanine Green IR-820 in Near-Infrared Fluorescence Imaging and Photothermal and Synergetic Therapy of Tumor

作者:: 朱丽君; 樊慧敏; 李慧; 杜仲; 王蕾; 张学良; 尼沙·阿力甫; 1. 新疆医科大学第二附属医院，新疆乌鲁木齐 830054 2. 新疆医科大学医学工程技术学院，新疆乌鲁木齐 830054 3. 新疆医科大学公共卫生学院，新疆乌鲁木齐 830054 el at

Author(s):: ZHU Lijun; FAN Huimin; LI Hui; DU Zhong; WANG Lei; ZHANG Xueliang; NUERNISHA Alifu; 1.The Second School of Clinical Medicine of Xinjiang Medical University, Urumqi 830054, China 2.School of Medical Engineering and Technology, Xinjiang Medical University, Urumqi 830054, China 3. Institute of Public Health, Xinjiang Medical University, Urumqi 830054, China et al.

Keywords:: organic fluorescent dye; new indocyanine green IR-820; near-infrared fluorescence (NIRF) imaging; photothermal therapy; synergistic therapy; tumor

摘要:: 新吲哚菁绿IR-820因其具有强近红外(nearinfrared, NIR, 750~1700 nm)荧光特性、良好生物相容性、高光热转换效率及稳定性等优势，在NIR发光的有机荧光染料中脱颖而出，被广泛应用于生物医学成像、荧光标记、细胞实时监测、光热治疗等研究领域。为更好地发挥IR820的生物医学应用价值，研究人员用不同生物化学分子修饰IR-820来增强其荧光及光热特性，制备多种类的荧光纳米粒子，在基础生物医学成像与肿瘤光热治疗方面开展了众多研究。总结了IR-820荧光纳米粒子在近红外荧光成像和通过光热机理及与其他技术协同治疗肿瘤中的应用研究，希望为进一步推进有机荧光染料IR-820在生物医学领域应用和临床转化发展提供参考。

Abstract:: With the advantages of strong near-infrared (NIR, 760~1700 nm) fluorescence emission, good biocompatibility, high photothermal conversion efficiency and good stability, the new indocyanine green IR-820 has stood out among the existing organic NIR fluorescent dyes and has been widely used in the research fields of biomedical imaging, fluorescent labeling, real-time cell monitoring and photothermal therapy. Researchers have modified IR-820 with different biochemical molecules to enhance its fluorescence and photothermal properties, multiple types of IR-820 fluorescent nanoparticles have been prepared and investigated in biomedical imaging and tumor photothermal therapy. This article has summarized the applications of the synthesized IR-820 nanoparticles in near-infrared fluorescence (NIRF) imaging and tumor photothermal therapy and synergistic therapy, aiming to provide a reference for the further development of NIR organic fluorescent dye IR-820 in the biomedical field and the further clinical translation.