钛基植入物表面抗菌涂层改性的研究进展-中国材料进展

文章信息/Info

Title:: Research Progress in the Modification of Antibacterial Coatings on Titanium Base Implants

作者:: 刘婉珍; 周文昊; 白天; 王岚; 牛金龙; 1.东北大学材料科学与工程学院，辽宁沈阳 110819 2.西北有色金属研究院，陕西西安 710016

Author(s):: LIU Wanzhen; ZHOU Wenhao; BAI Tian; WANG Lan; NIU Jinlong; 1.School of Materials Science and Engineering, Northeastern University, Shenyang 110819, China 2.Northwest Institute for Non-ferrous Metal Research, Xi‘an 710016, China

Keywords:: titanium alloy; implants; antibacterial; coating; osseointegration

摘要:: 钛及其合金得益于无毒、质轻、耐腐蚀性、可加工性和生物相容性好等优点，是需要承受较高载荷的骨、齿等硬组织修复和替换的主要基体材料，目前在临床上使用广泛。但是，未经处理的钛表面通常不具备抗菌性能，容易造成植入体感染，从而导致植入失败，因此需要在钛基植入物表面构建抗菌涂层赋予其抗菌能力。研究表明，抑制植入体表面的早期细菌粘附和生物膜的形成是防治感染的主要策略。从抗菌机理方面入手，综述了抗粘附型抗菌涂层、释放杀菌以及接触杀菌涂层的最新研究进展，重点阐述了光动力杀菌和pH响应杀菌这2种新型的杀菌方式，并对多种抗菌剂联用的协同杀菌策略进行了总结，最后对钛基植入物表面抗菌涂层改性未来的发展进行了展望。

Abstract:: Titanium and its alloy are the main matrix materials for the repair and replacement of bone, teeth and other hard tissues that need to bear a high load due to their advantages of non-toxic, light weight, corrosion resistance, machinability and good biocompatibility, and are widely used in clinical practice. However, untreated titanium surface usually does not have antibacterial properties, which is easy to cause implant infection, resulting in implantation failure. Therefore, it is necessary to construct antibacterial coating on the surface of titanium implant to give it antibacterial ability. Studies have shown that inhibiting early bacterial adhesion and biofilm formation are the main strategies to prevent and control infection. Starting from the aspect of antibacterial mechanism, this paper reviews the latest research progress of anti-adhesion antibacterial coating, release bactericidal coating and contact bactericidal coating, focuses on the photodynamic bactericidal and pH response bactericidal two new bactericidal methods, and summarizes the cooperative bactericidal strategy of multiple antibacterial agents. Finally, the future development of antibacterial coating on the surface of titanium implants is prospected.