铜纳米粒子在有机合成中的应用-中国材料进展

文章信息/Info

作者:: 王嗣昌; 王力婷; 袁铭; 张攀; 孙妩娟; 柯从玉; 1. 西安石油大学化学化工学院，陕西西安 710065 2. 上海优合贝德医药科技有限公司，上海 201210

Author(s):: WANG Sichang; WANG Liting; YUAN Ming; ZHANG Pan; SUN Wujuan; KE Congyu; 1. College of Chemistry and Chemical Engineering, Xi’an Shiyou University, Xi‘an 710065, China 2. Unibestpharma Technology Co., Ltd., Shanghai 201210, China

Keywords:: copper nanoparticles; organic synthesis; triazoles; tetrazoles; oxidation; reduction; coupling

摘要:: 随着纳米技术的飞速发展，铜纳米粒子因其独特的物理化学性质，如高活性、大比表面积和良好的选择性，在有机合成中展现了广泛的应用前景。讨论了新型铜纳米材料在各种类型有机反应中的应用，包括多组分“一锅法”反应合成药物活性分子、炔叠氮化合物环加成反应合成三唑和四唑衍生物、醇的选择性氧化反应、硝基的还原反应、C—X（C，N，O）偶联反应（其中C—C偶联包括Mizoroki-Heck、SuzukiMiyaura、Glaser-Hay等偶联反应；C—N及C—O偶联包括ChanLam、Buchwald-Hartwig、Ullmann、Goldberg等偶联反应）。大多数铜纳米粒子催化反应具有反应操作简单、反应条件温和、催化效率高、官能团耐受性好、成本低、反应体系干净且铜催化剂可重复使用等优点。铜纳米粒子在有机合成中的应用将对有机合成方法学产生重要影响，并促进有机铜化学的进一步发展。

Abstract:: With the rapid development of nanotechnology, copper nanoparticles have shown a broad application prospect in organic synthesis due to their unique physical and chemical properties, such as high activity, large specific surface area and good selectivity. This review discusses the application of new copper nanomaterials in various types of organic reactions, including multicomponent “one pot” reaction for the synthesis of drug active molecules, acetylene azide cycloaddition reaction for the synthesis of triazole and tetrazole derivatives, selective oxidation of alcohols, reduction of nitro groups, C—X (C, N, O) coupling reactions (C—C coupling includes Mizoroki-Heck, SuzukiMiyaura, Glaser-Hay and other coupling reactions; C—N and C—O coupling reactions include Chan-Lam, Buchwald-Hartwig, Ullmann, Goldberg, etc). Most copper nanoparticles catalytic reactions have the advantages of simple operation, mild reaction conditions, high catalytic efficiency, good tolerance of functional groups, low cost, clean reaction system and reusable copper catalyst. These applications of copper nanoparticles in organic synthesis will have an important impact on methodology of organic synthesis and promote the further development of organic copper chemistry.