磁性贴片的几何结构参数对均匀性吸附磁性微粒的影响-中国材料进展

文章信息/Info

Title:: Influence of Geometric Structural Parameters of Magnetic Patches on the Uniform Adsorption of Magnetic Particles

作者:: 裴宁; 董耀诚; 龚永勇; 白逸凡; 沈运丽; 1. 上海大学理学院，上海 200444 2. 郑州外国语中学，河南郑州 450006 3. 同济大学上海东方医院，医学院心内科，上海 200092

Author(s):: PEI Ning; DONG Yaocheng; GONG Yongyong; BAI Yifan; SHEN Yunli; 1. School of Science, Shanghai University, Shanghai 200444, China 2. Zhengzhou Foreign Language Middle School, Zhengzhou 450006, China 3. Department of Cardiology, Shanghai East Hospital, Tongji University, Shanghai 200092, China

Keywords:: magnetic biological patch; magnetic particles; magnetic targeting; numerical simulation; uniform adsorption

摘要:: 在磁靶向治疗中,磁性粒子的非均匀分布会增大局部组织微循环栓塞的风险。研究了磁性生物贴片(ferromagnetic biological patch, MBP)的几何参数对贴片吸附磁性微粒的均匀性的影响。利用数值仿真方法，研究了MBP局域磁场的磁通密度及其梯度随MBP几何参数和外磁场强度的变化规律。MBP的聚磁作用随着贴片厚度T的增加、外磁场B0的增强、距离H的减小而增强。通过在贴片中心设置空气孔，当空气孔孔径（略小于临界直径Db0）和间距合适时，可以使孔之间形成磁通密度极大值，使贴片中间、孔中心和贴片边缘都能吸附较多微粒。MBP中心空气孔孔径为040 mm时能够较均匀地吸附磁性微球，与仿真结果相吻合。

Abstract:: In magnetic drug targeting therapy, the nonuniform distribution of magnetic particles can elevate the risk of local tissue microcirculation embolism. This study employed a ferromagnetic biological patch (MBP) to explore the influence of the geometric parameters of the MBP on the uniformity of magnetic microparticle adsorption. The effects of geometric parameters of the MBP and the magnetic flux density of external magnetic field（MF）on the local inhomogeneous MF around the MBP were investigated based on numerical simulation．The magnetic concentrating effect of the MBP is enhanced with the increase in the patch thickness T and the augmentation of the external MF B0 and the decrease in the distance H from the patch. By setting bores at the center of the patch, when the bores diameter (slightly smaller than the critical diameter Db0) and the spacing are appropriate, the maximum magnetic flux density can be formed between the bores, and both the center and the edge of the patch, as well as the center of pores, can adsorb magnetic particles uniformly. The MBP with a central bore diameter of 0.40 mm can adsorb magnetic microspheres in a relatively uniform manner, which is aligned with the simulation results.