环四硅氧烷荧光探针及其对Fe3+的检测-中国材料进展

文章信息/Info

Title:: Cyclotetrasiloxane Fluorescence Probe and Specific Detection Application of Fe3+ Ions

作者:: 周凯丽; 邓卫星; 李晓丽; 黄俊浩; 谢婷婷; 唐艳平; 1. 桂林理工大学材料科学与工程学院，广西桂林 541000 2. 桂林师范学院化学与生命健康学院，广西桂林 541199

Author(s):: ZHOU Kaili; DENG Weixing; LI Xiaoli; HUANG Junhao; XIE Tingting; TANG Yanping; 1. College of Materials Science and Engineering, Guilin University of Technology, Guilin 541004, China; 2. Department of Chemistry and Pharmacy, Guilin Normal College, Guilin 541199, China

Keywords:: tetramethylcyclotetrasiloxane(D4H); cipro-floxacin; Fe3+ ion detection; fluorescent probe

摘要:: 铁元素是哺乳动物体内含量最丰富的过渡金属，对维持生命活动和健康至关重要，铁元素的缺乏和过量都会导致严重的疾病，因此铁离子的检测具有重要的意义。通过硅氢化反应制备了环丙沙星接枝四甲基环四硅氧烷D4H-HBC，并利用核磁、紫外和荧光光谱仪等对其化学结构和光谱特性进行了表征。研究表明，D4H-HBC是一种优异的Fe3+荧光探针，当Fe3+的浓度在5.5×10-5 mol/L以内时能够线性地测定其浓度，检测极限为0.33 μmol/L，远低于美国国家环境保护局限定的Fe3+安全浓度上限。对D4H-HBC对Fe3+的检测机理研究表明，三价铁离子以其合适的离子半径，与D4H-HBC环上3个空位的硅氢形成络合体，导致D4H-HBC荧光猝灭。环四硅氧烷荧光探针对Fe3+有良好的选择性，并为环状荧光探针的设计提供了新的思路。

Abstract:: Iron is the most abundant transition metal in mammals, which is essential for maintaining life activities and health, and both deficiency and excess of iron can lead to serious diseases, so the detection of iron ions is of great significance. In this paper, ciprofloxacin grafted tetramethylcyclotetrasiloxane (D4H-HBC) was prepared by hydrosilylation. The chemical structure and optical characteristics were characterized by NMR, UV and fluorescence spectroscopy. D4H-HBC is an excellent Fe3+ fluorescence probe, linearly concentration dependent quenching was observed when the concentration of Fe3+ is less than 5.5×10-5 mol/L, and the detection limit is 0.33 μmol/L, much below the safe concentration limit for Fe3+ ions set by the U-S. Environmental Protection Agency. The quenching mechanism of D4H-HBC is most probably due to the formation of complex between the trivalent iron ions and three silicon hydrogen bonds at three vacancies on the D4H-HBC ring.Cyclotetrasiloxane fluorescent probe has good selectivity for Fe3+ and this work provides a new idea for the design of cyclic fluorescent probe.