镓负载生物材料在组织修复应用中的研究进展-中国材料进展

文章信息/Info

Title:: Research Progress on the Application of Gallium-Loaded Biomaterials in Tissue Repair

作者:: 吴宛泽; 陈朋; 赵子新; 周艳艳; 许零; 1. 厦门大学深圳研究院，广东深圳 518000 2. 厦门大学公共卫生学院传染病疫苗研发全国重点实验室翔安创新实验室，福建厦门 361102

Author(s):: WU Wanze; CHEN Peng; ZHAO Zixin; ZHOU Yanyan; XU Ling; 1. Shenzhen Research Institute of Xiamen University, Shenzhen 518000, China 2. Xiang An Biomedicine Laboratory, State Key Laboratory of Vaccines for Infectious Diseases,School of Public Health, Xiamen University, Xiamen 361102, China

Keywords:: biomaterials; tissue repair; antimicrobial; gallium; gallium-loaded biomaterials

摘要:: 镓负载生物材料因其独特的物理、化学及生物学特性，在抗菌、促进细胞增殖、血管生成和组织修复方面具有积极作用。镓离子能够通过与铁离子竞争抑制细菌生长，尤其对多种耐药性细菌具有显著抑制作用。此外，镓负载材料通过调节细胞行为、促进新血管形成以及增强组织再生，在促进伤口愈合中展现出巨大的潜力。随着对镓基生物材料的深入研究，其有望成为伤口愈合修复应用的重要工具，为临床治疗及选择提供创新方案。对镓基生物材料在伤口愈合中的研究进展进行了综述，重点探讨了其生物活性机制、临床应用前景及未来发展方向。

Abstract:: Gallium-loaded biomaterials exhibit positive effects in antibacterial activity,promotion of cell proliferation, angiogenesis and tissue repair due to their unique physical, chemical and biological properties. This binding disrupts bacterial iron metabolism and inhibits bacterial growth, making it particularly effective against multidrug-resistant bacteria, which are a major concern in clinical settings. Furthermore, gallium-loaded biomaterials promote cell proliferation, angiogenesis and tissue regeneration, which are critical for accelerating wound healing. These effects are attributed to the modulation of cellular behavior and enhancement of new blood vessel formation, ultimately creating a favorable microenvironment for tissue repair. The clinical applications of gallium-loaded biomaterials in wound healing are promising. This article reviews the research progress of gallium-based biomaterials in wound healing, focusing on biological activity mechanisms, clinical application prospects and future development directions.