新型介入生物栓塞材料的研究进展-中国材料进展

文章信息/Info

作者:: 汤景文; 张磊; 东南大学医学院，东南大学附属中大医院介入与血管外科，智能影像与介入医学国家级重点实验室培育建设点（东南大学），江苏南京，210009

Author(s):: Tang Jingwen; Zhang Lei; Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China

Keywords:: embolic materials; interventional therapy; mechanical devices; solid particle embolic agents; liquid embolic agents

摘要:: 随着材料科学的不断发展，越来越多的生物栓塞材料被应用于介入医学领域。血管栓塞治疗已成为治疗良恶性肿瘤及出血、动静脉畸形、动脉瘤等血管相关疾病的常用治疗手段。生物栓塞材料分为机械装置、固体颗粒栓塞剂、液体栓塞剂、液-固相转换栓塞剂等。其中，明胶海绵、碘化油、聚乙烯醇等已经进入到临床应用阶段，但这些栓塞材料的理化性质、生物学功能仍有待提高。介入生物栓塞材料由功能单一向具有多功能集成、多模态成像、降解可控与良好可操控性的智能响应型栓塞材料发展。本文对生物栓塞材料在介入治疗中的作用、分类及演化进行了综述。

Abstract:: With the continuous development of materials science, an increasing number of bio-embolic materials have been applied in the field of interventional medicine. Vascular embolization has become a commonly used therapeutic approach for benign and malignant tumors, as well as vascular-related diseases such as hemorrhage, arteriovenous malformations, and aneurysms. Bio-embolic materials can be classified into mechanical devices, solid particulate embolic agents, liquid embolic agents, and liquid-to-solid phase-transition embolic agents, among others. Among them, gelatin sponge, iodized oil, and polyvinyl alcohol have already entered clinical application; however, the physicochemical properties and biological functions of these embolic materials still require further improvement. Interventional bio-embolic materials are evolving from single-function materials toward intelligent responsive embolic materials with multifunctional integration, multimodal imaging capability, controllable degradation, and favorable maneuverability. This article reviews the role, classification, and evolution of bio-embolic materials in interventional therapy.