[1]梁文俊、孟思平、王迪、白旭明、靳勇、孙兴伟.磁热微球增效肝恶性肿瘤介入治疗的研究进展[J].中国材料进展,2026,45(06):050-59.
　LIANG Wenjun,MENG Siping,WANG Di,et al.Research Progress on Magnetic Hyperthermal Microspheres for Enhancing Interventional Therapy of Malignant Liver Tumors[J].MATERIALS CHINA,2026,45(06):050-59.
点击复制

磁热微球增效肝恶性肿瘤介入治疗的研究进展()

中国材料进展[ISSN:1674-3962/CN:61-1473/TG]

卷:
45
期数:
2026年06
页码:
050-59
栏目:
出版日期:
2026-05-31

文章信息/Info

Title:
Research Progress on Magnetic Hyperthermal Microspheres for Enhancing Interventional Therapy of Malignant Liver Tumors
作者:
梁文俊、孟思平、王迪、白旭明、靳勇、孙兴伟
苏州大学附属第二医院介入放射科，中国苏州 215004
Author(s):
LIANG Wenjun; MENG Siping; WANG Di; BAI Xuming; JIN Yong; SUN Xingwei
Department of Interventional Radiology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
关键词:
磁热微球; 肿瘤介入; 肝恶性肿瘤; 肝动脉化疗栓塞; 协同治疗
Keywords:
Magnetic Hyperthermal Microspheres;  Interventional Oncology;  Hepatic Malignancies;  Transarterial Chemoembolization;  Synergistic Therap
文献标志码:
A
摘要:
肝恶性肿瘤是全球范围内的重大健康威胁，经动脉化疗栓塞术（TACE）已成为肝恶性肿瘤中晚期患者的标准疗法，但仍面临肿瘤缺氧耐药，术后复发瓶颈。磁热微球 (MHMs) 作为一种集物理栓塞与磁热疗 (MHT) 于一体的新型介入手段，通过在交变磁场 (AMF) 下将磁能转化为热能，实现了对肿瘤的精准干预。本文系统综述了磁热微球的多样化制备工艺（如光聚合、微流体技术及喷雾干燥等），并探讨了其产热机制与比吸收率 (SAR)、固有损耗功率 (ILP) 等关键评估指标。重点分析了磁热微球在联合化疗栓塞 (TACE)、放射性栓塞 (TARE) 及免疫治疗中的协同策略，指出其在克服肿瘤缺氧耐药、增强放射敏感性及诱导免疫原性细胞死亡 (ICD) 以重塑肿瘤微环境（将“冷”肿瘤转变为“热”肿瘤）方面的巨大潜力。尽管临床前研究成果显著，但磁热微球在精准温控监测、长期生物安全性、设备小型化及行业标准建立等方面仍面临挑战。未来研究需致力于构建集成化诊疗系统和个体化方案，以加速其临床转化进程。
Abstract:
Hepatic malignancies represent a formidable global health threat. While transarterial chemoembolization (TACE) has emerged as the gold standard therapy for patients with intermediate-to-advanced stage hepatic malignancies, its efficacy is frequently compromised by hypoxia-induced drug resistance and high postoperative recurrence rates. Magnetic hyperthermia microspheres (MHMs), as a novel interventional modality integrating physical embolization with magnetic hyperthermia therapy (MHT), achieve precise tumor intervention by converting magnetic energy into thermal energy under an alternating magnetic field (AMF).This review systematically summarizes the diverse fabrication techniques for MHMs, such as photopolymerization, microfluidics, and spray drying, and discusses their heat-generation mechanisms alongside critical evaluation metrics, including specific absorption rate (SAR) and intrinsic loss power (ILP). Furthermore, we highlight the synergistic strategies of MHMs in combination with TACE, transarterial radioembolization (TARE), and immunotherapy. Emphasis is placed on their immense potential to overcome hypoxia-driven resistance, enhance radiosensitivity, and induce immunogenic cell death (ICD) to remodel the tumor microenvironment (effectively converting "cold" tumors into "hot" ones). Despite significant preclinical advancements, challenges remain regarding precise thermometry, long-term biosafety, equipment miniaturization, and the establishment of industry standards. Future research should focus on the development of integrated theranostic systems and personalized therapeutic protocols to accelerate the clinical translation of MHMs. Key words:Magnetic Hyperthermal Microspheres; Interventional Oncology; Hepatic Malignancies; Transarterial Chemoembolization; Synergistic Therapy
更新日期/Last Update: 2026-05-14