无机介入生物材料：从基础研究到临床转化-中国材料进展

文章信息/Info

Title:: Inorganic Interventional Biomaterials: From Basic Research to Clinical Translation

Author(s):: GONG Fei; DU Qialu; YANG Nailin; CHENG Liang; Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China

Keywords:: HCC treatment; TAE/TACE; inorganic biomaterials; tumor microenvironment; combination therapy

摘要:: 目前全球肝癌（hepatocellular carcinoma, HCC）新发病例数位居第六位，死亡率却高居第三位，极大威胁人类生命健康。针对不可切除肝癌患者，经动脉栓塞/化疗栓塞（transarterial embolization/chemoembolization, TAE/TACE）已经成为临床一线治疗方案，具有优异的治疗效果和较低的副作用。然而，肝肿瘤动脉栓塞后，肿瘤微环境会进一步恶化（如乏氧、酸性pH、血管异常及免疫抑制等），从而增加肿瘤复发与转移风险，导致TAE/TACE治疗失败。针对上述肿瘤微环境问题，作者团队近年来围绕创新无机生物介入材料，开展从基础研究到临床转化的应用探索。重点总结作者团队关于创新无机生物介入材料及其调控肿瘤微环境、逆转肿瘤免疫抑制、联合外源刺激等增效TAE/TACE治疗，以及创制栓塞微球早期临床探索等相关工作，相关研究已使肝癌患者切实获得显著的治疗效果。最后，指出当前TACE治疗存在的局限与介入栓塞材料未来发展方向，以期加速介入生物材料的临床转化。

Abstract:: Hepatocellular carcinoma (HCC) has the sixth-highest new incidence and third-highest mortality worldwide. Transarterial embolization/chemoembolization (TAE/TACE) remains the gold standard for treating unresectable HCC.However,the therapeutic effect is still unsatisfactory due to the worsening of the post-embolization tumor microenvironment (e.g. hypoxia, reduced pH, angiogenesis,and immunosuppression), which increases the risks of the tumor recurrence and metastasis. To address these issues, we have conducted translational research from bench to bedside on innovative inorganic bio-interventional materials. This review mainly summarizes our recent work on enhancing TAE/TACE therapy via innovative materials that regulate the tumor microenvironment, reverse immunosuppression, and synergize with exogenous stimuli, and introduces the early clinical exploration of the developed microspheres that have brought substantial therapeutic benefits to HCC patients. Last, this review also highlight the limitations and future directions in TACE to accelerate the clinical translation of these inorganic interventional biomaterials.