[1]刘珮瑶,毛纯柯,邹涛,等.肿瘤微环境调控导向的介入栓塞材料研究进展[J].中国材料进展,2026,45(06):518-532.[doi:10.7502/j.issn.1674-3962.202604030]
　LIU Peiyao,MAO Chunke,ZOU Tao,et al.Advances in Tumor Microenvironment-Oriented Transarterial Embolic Materials[J].MATERIALS CHINA,2026,45(06):518-532.[doi:10.7502/j.issn.1674-3962.202604030]
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肿瘤微环境调控导向的介入栓塞材料研究进展()

中国材料进展[ISSN:1674-3962/CN:61-1473/TG]

卷:
45
期数:
2026年06
页码:
518-532
栏目:
出版日期:
2026-05-31

文章信息/Info

Title:
Advances in Tumor Microenvironment-Oriented Transarterial Embolic Materials
文章编号:
1674-3962(2026)06-0518-15
作者:
刘珮瑶; 毛纯柯; 邹涛; 王向东; 陈敏江
1. 温州医科大学附属第五医院，浙江 丽水 323000 2. 兰州理工大学生命科学与工程学院，甘肃 兰州730050
Author(s):
LIU Peiyao;  MAO Chunke;  ZOU Tao;  WANG Xiangdong;  CHEN Minjiang
1. The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China 2. School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China
关键词:
经导管动脉栓塞; 肿瘤微环境; 栓塞材料; 免疫调控; 肝细胞癌
Keywords:
transcatheter arterial embolization;  tumor microenvironment;  embolic materials;  immune regulation;  hepatocellular carcinoma
分类号:
TB383; R318.08
DOI:
10.7502/j.issn.1674-3962.202604030
文献标志码:
A
摘要:
经导管动脉栓塞及其衍生技术，如经导管动脉化疗栓塞和经导管动脉放射栓塞，已成为富血供实体肿瘤的重要局部治疗手段，尤其在中晚期肝细胞癌中应用广泛。然而，现有治疗仍以姑息性控制为主，其疗效受限于单纯血流阻断所诱导的肿瘤适应性反应，包括缺氧驱动的新生血管形成、代谢重编程及免疫抑制性肿瘤微环境（tumor microenvironment，TME）的建立，最终导致肿瘤复发与进展。研究表明，栓塞过程不仅是机械性血流阻断事件，更是伴随TME动态重塑的复杂生物学过程。传统栓塞材料与药物洗脱微球主要依赖被动血管阻断，仍缺乏对栓塞后TME演化过程的主动调控能力。因此，介入栓塞材料正由单一栓塞功能向TME调控导向的多维度设计转变，通过结构与功能协同，实现对缺氧、代谢及免疫微环境的系统干预。围绕这一设计思路转变，从空间调控、时序编程释放、信号响应及外场能量驱动等方面总结栓塞材料的结构设计与作用机制，并探讨其在免疫重塑及不同临床场景中的应用前景，以期为介入栓塞治疗的优化与转化提供理论支持。
Abstract:
Transarterial embolization and its derivative techniques, including transarterial chemoembolization and transarterial radioembolization, have become established locoregional therapies for hypervascular solid tumors, particularly in intermediate and advanced-stage hepatocellular carcinoma. However, their clinical efficacy remains largely palliative, as therapeutic outcomes are constrained by adaptive tumor responses induced by vascular occlusion,including hypoxia-driven angiogenesis, metabolic reprogramming and the establishment of an immunosuppressive tumor microenvironment (TME), ultimately leading to tumor recurrence and progression. Emerging evidence indicates that embolization is not merely a mechanical vascular occlusion process, but a dynamic biological event accompanied by profound remodeling of the TME. Conventional embolic agents and drugeluting microspheres primarily rely on passive vascular occlusion and lack the capability to actively regulate post-embolization TME evolution. Consequently, interventional embolic materials are shifting from single-functional vascular blockage toward TMEoriented multifunctional design, enabling coordinated regulations of hypoxia,metabolic and immune components through integrated structural and functional engineering. This review summarizes recent advances in embolic materials from the perspectives of spatial regulation, temporally programmed release, stimulus-responsive systems and externally triggered energy-driven platforms. Furthermore, it discusses novel embolic materials-roles in immune reprogramming and different clinical scenarios, aiming to provide a reference for the optimization and translational development of interventional embolization strategies.

备注/Memo

备注/Memo:
收稿日期：2026-04-30修回日期：2026-05-14 基金项目：国家自然科学基金资助项目（82472088）；浙江省自然科学基金资助项目（LLSSZ24H180001） 第一作者：刘珮瑶，女，2002年生，硕士研究生 通讯作者：陈敏江，男，1990年生，研究员，博士生导师， Email:minjiangchen@wmu.edu.cn
更新日期/Last Update: 2026-06-10