[1]陈昌盛,李仕颖,王俊,等.小分子硼酸肽的自组装[J].中国材料进展,2012,(6):049-54.[doi:10.7502/j.issn.1674-3962.2012.06.08]
　CHEN Changsheng,LI Shiying,WANG Jun,et al.Self-Assembly of Oligo-Borono-Peptides[J].MATERIALS CHINA,2012,(6):049-54.[doi:10.7502/j.issn.1674-3962.2012.06.08]
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小分子硼酸肽的自组装()

中国材料进展[ISSN:1674-3962/CN:61-1473/TG]

卷:
期数:
2012年第6期
页码:
049-54
栏目:
特约研究论文
出版日期:
2012-06-25

文章信息/Info

Title:
Self-Assembly of Oligo-Borono-Peptides
作者:
陈昌盛; 李仕颖; 王俊; 张先正; 卓仁禧
（武汉大学化学与分子科学学院 生物医用高分子材料教育部重点实验室，湖北 武汉 430072）
Author(s):
CHEN Changsheng;  LI Shiying;  WANG Jun;  ZHANG Xianzheng;  ZHUO Renxi
（Key Laboratory of Biomedical Polymers of Education Ministry, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China）
关键词:
硼酸肽; 自组装; 超分子聚集体; 纳米材料
DOI:
10.7502/j.issn.1674-3962.2012.06.08
文献标志码:
A
摘要:
利用FMOC化学固相多肽合成法合成了3种含精氨酸的小分子硼酸肽（标记为BPs（13））。在生理pH下，含阳离子的硼酸肽可自组装形成有序超分子纳米组装体。二羟基酚染料茜素红与硼酸肽可特异性结合形成五元环硼酸酯，伴随荧光和颜色的显著变化，可进一步调控硼酸肽的自组装行为。通过扫描电镜研究茜素红调控前后硼酸肽的自组装形态，并用红外光谱和圆二色谱研究其自组装机理。结果表明，3种含精氨酸硼酸肽在生理pH下可自组装形成不同的超分子纳米组装体。通过茜素红的调控，茜素红/硼酸肽化合物，可自组装形成更有序，更精致的超分子聚集体。
Abstract:
Three arginine containing oligo borono peptides (BPs(1 3)) were synthesized by employing a standard FMOC chemistry SPPS. BPs(13) could spontaneously selfassemble into supramolecular architectures at a physiological environment. With recognition between BPs and alizarin red S (ARS), the fivemembered ring borate esters (ARS/BPs) could be formed with dramatic changes in fluorescent feature and visible color. These selfassembled supramolecular architectures were observed by scanning electron microscope (SEM) and their selfassembly mechanisms were explored by Fourier Transform Infrared Spectroscopy (FTIR) and Circular Dichroism (CD). It was found that BPs were capable of selfassembling into wellordered supramolecular architectures, and after recognition of ARS, ARS/BPs could further selfassemble into more ordered and sophisticated supramolecular architectures.
更新日期/Last Update: 2012-07-26