高强韧与响应型高分子水凝胶研究进展-中国材料进展

文章信息/Info

Author(s):: GAO Guorong; DU Gaolai; SUN Yuanna; FU Jun; Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences

摘要:: 高分子水凝胶与生物组织的结构和性能比较相似，生物相容性和生物安全性好，被广泛应用于组织工程、药物输送、创伤敷料等领域，具有非常广阔的应用前景。发展具有高强韧性能和响应功能的高分子水凝胶，是近年来研究的热点和难点。综述了近 10 年来代表性的纳米复合水凝胶、双网络水凝胶、响应型水凝胶等新型高分子水凝胶方面的重要研究进展，总结了其设计与合成的基本原理和方法，介绍了几种典型的高强度和韧性高分子水凝胶的增强增韧机理和能量耗散机制，阐述了基于阳离子、阴离子及两性离子单体的智能响应型高分子水凝胶的应激响应原理和特性。在此基础上，分析讨论了高强韧与响应型高分子水凝胶作为潜在生物材料仍需解决的关键科学问题，并对本领域的发展趋势进行了展望。

Abstract:: Due to their similarities to bio-tissues, and excellent biocompatibility and biosafety, polymer hydrogels have been widely studied for potential applications in tissue engineering, drug delivery, and wound dressing, etc. The development of tough and responsive hydrogels has recently been a very hot topic with great challenges. In this review, progresses in the development of novel hydrogels including nanocomposite hydrogels, double network hydrogels and responsive hydrogels in last decade are reviewed. Several imporant design philosophy and synthesis method are accounted. The toughening mechanisms and energy dissipation mechanisms of a few representative strong and tough polymer hydrogels are introduced. Moreover, some smart and stimuli-responsive hydrogels based on cationic, anionic, and zwitteronic monomers are reviewed and discussed in detail. Based on these progresses, the major challenges of strong, tough, and responsive hydrogels as biomaterials are analyzed. Finally, the perspectives of tough and responsive hydrogels were discussed.