[1]郑 静,陈 琳,张 欢,等.磁性有序介孔纳米碳靶向药物载体的制备与控释性能[J].中国材料进展,2018,(01):043-50.[doi:10.7502/j.issn.1674-3962.2018.01.07]
 ZHENG Jing,CHEN Lin,ZHANG Huan,et al.Preparation and Controlled Release Performance of Magnetic Ordered Mesoporous CarbonNanospheres as Targeted Drug Carrier[J].MATERIALS CHINA,2018,(01):043-50.[doi:10.7502/j.issn.1674-3962.2018.01.07]
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磁性有序介孔纳米碳靶向药物载体的制备与控释性能()
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中国材料进展[ISSN:1674-3962/CN:61-1473/TG]

卷:
期数:
2018年第01期
页码:
043-50
栏目:
前沿综述
出版日期:
2018-01-31

文章信息/Info

Title:
Preparation and Controlled Release Performance of Magnetic Ordered Mesoporous CarbonNanospheres as Targeted Drug Carrier
作者:
郑  静陈  琳张  欢杨永珍刘旭光许并社
(1.太原理工大学 新材料界面科学与工程教育部重点实验室,山西 太原 030024)(2.太原理工大学化学化工学院,山西 太原 030024)(3.太原理工大学 新材料工程技术研究中心,山西 太原 030024)(4.太原理工大学材料科学与工程学院,山西 太原 030024)
Author(s):
ZHENG Jing12 CHEN Lin13 ZHANG Huan12YANG Yongzhen13 LIU Xuguang14 XU Bingshe13
(1.Key Laboratory of Interface Science and Engineering in Advanced Materials of Ministry of Education,Taiyuan University of Technology, Taiyuan 030024, China)(2.College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China)(3.Research Center on Advanced Materials Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China)(4.College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China)
关键词:
有序介孔纳米碳磁靶向药物缓释控释性能盐酸阿霉素
Keywords:
ordered mesoporous carbon nanospheres magnetic targeting drug delivery controlled release doxorubicin hydrochloride
DOI:
10.7502/j.issn.1674-3962.2018.01.07
文献标志码:
A
摘要:
药物的靶向控释已成为肿瘤化疗研究的热点。以有序介孔纳米碳球(OMCNs)为基质,先后对其进行磁化、氨基和肼基修饰,最终制得可与抗肿瘤药物盐酸阿霉素(DOX)共价结合的磁靶向药物载体(HMOMCNs)。利用场发射扫描电子显微镜、X射线衍射分析仪、热重分析仪、傅里叶变换红外分析仪、紫外-可见分光光度计等分析手段对HMOMCNs进行结构表征和性能评价。结果显示:HMOMCNs的粒径约为100 nm左右,具有丰富的孔道结构,对DOX的最大载药量为529.18 mg·g-1;HMOMCNs对DOX具有pH控释性,随着pH的降低,其累积释药率增加,当pH降至5.5时,10 h累积释药率达到最大,最大值为76%。
Abstract:
The controlled release behavior of targeted drug delivery has attracted widespread concern. In this paper, magnetic targeted drug carrier (HMOMCNs), which can covalently bond to anti-cancer drug doxorubicin hydrochloride (DOX), was synthesized from ordered mesoporous carbon nanospheres (OMCNs) through magnetization, amination and hydrazine modification. The structural characterization and performance evaluation of HMOMCNs were carried out by field emission scanning electron microscopy, X-ray diffraction analyzer, thermogravimetric analyzer, Fourier transformation infrared spectroscopy and ultraviolet-visible spectrophotometer. The results showed that the HMOMCNs had a particle size of about 100 nm with good ordered mesoporous structure, and the maximum drug loading capacity was 529.18 mg·g-1. The release of DOX from HMONCNs can be controlled by pH values. With the decrease of the pH value, the cumulative release rate increased. When pH was 5.5, the cumulative release rate was 76% and reached the equilibrium for about 10 h.
更新日期/Last Update: 2018-02-07