[1]谢园园,刘硕,王斌.氧化铁纳米颗粒示踪干细胞的临床转化研究进展[J].中国材料进展,2019,(06):567-576.[doi:10.7502/j.issn.1674-3962.201810009]
 Xie Yuanyuan,Liu Shuo,Wang Bin.Research Progresses on Clinical Translation of Iron Oxide Nanoparticles in Stem Cell Tracing[J].MATERIALS CHINA,2019,(06):567-576.[doi:10.7502/j.issn.1674-3962.201810009]
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氧化铁纳米颗粒示踪干细胞的临床转化研究进展()
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中国材料进展[ISSN:1674-3962/CN:61-1473/TG]

卷:
期数:
2019年第06期
页码:
567-576
栏目:
特约研究论文
出版日期:
2019-06-30

文章信息/Info

Title:
Research Progresses on Clinical Translation of Iron Oxide Nanoparticles in Stem Cell Tracing
作者:
谢园园刘硕王斌
南京大学医学院附属鼓楼医院 临床干细胞研究室
Author(s):
Xie Yuanyuan Liu Shuo Wang Bin
Clinical Stem Cell Center, the Affiliated Drum Tower Hospital of Nanjing University Medical School
关键词:
氧化铁纳米颗粒超顺磁性磁共振成像干细胞示踪技术临床转化
Keywords:
iron oxide nanoparticles superparamagnetic magnetic resonance imaging stem cells tracing clinical transformation
DOI:
10.7502/j.issn.1674-3962.201810009
文献标志码:
A
摘要:
氧化铁纳米颗粒由纳米结构的氧化铁分子和表面包被的有机或无机涂层组成,具有独特的磁性和优异的生物相容性,在医学领域中应用非常广泛。当氧化铁纳米颗粒核心的氧化铁直径小于10~15 nm时,在一定温度范围内表现出超顺磁性,常用于磁共振成像,并且已经有多种基于超顺磁性氧化铁纳米颗粒的相关产品批准用于临床。在人体,移植干细胞在体内的迁移、分布和归巢仍然没有有效的示踪方法,严重制约着研究人员了解干细胞治疗机理及评价治疗效果,而超顺磁性氧化铁纳米颗粒与磁共振成像技术的结合为干细胞示踪的临床转化带来了希望,并将有望成为干细胞示踪的“金标准”,但是目前还未有任何纳米铁剂批准用于临床干细胞标记和体内示踪。综述了纳米铁颗粒在干细胞示踪方面的临床转化研究现状,以及面临的机遇和挑战,并展望了今后的发展方向与前景。
Abstract:
The iron oxide nanoparticles are composed of nanostructured iron oxide molecules and organic (or inorganic) surface coatings, which have unique magnetic properties and excellent biocompatibility, and are widely used in medical field. As long as the diameter of iron oxide core is less than 10~15 nm, they exhibits superparamagnetism in a certain temperature range, which is often used for magnetic resonance imaging. Up to now, a variety of products based on superparamagnetic iron oxide nanoparticles have been approved for various clinical uses. So far, there is no effective method for tracing migration, distribution, and homing of the transplanted stem cells in human, heavily hampering the mechanism and efficacy researches of stem cell-based products. The combination of superparamagnetic iron oxide nanoparticles and magnetic resonance imaging technology brings a hope for clinical translation of stem cell tracing, which is expected to become “the gold standard” for stem cell tracing in future. However, there is no relevant nano-iron approved as clinical stem cell tracing markers in clinic setting so far. This article reviews research progresses of nano-iron particles in stem cell tracing clinical translation, the facing opportunities and challenges, also gives a prospects for the development in the future.

备注/Memo

备注/Memo:
收稿日期:2018-10-15 修回日期:2018-11-14
基金项目:国家重点研发计划项目(2017YFA0104304);国家自然科学基金资助项目(81800583,81571213);江苏省第十三批“六大人才高峰”项目(WSN155);南京市“十三五”规划重点项目(ZDX16002)
第一作者:谢园园,女,1993年生,检验技师
通讯作者:王斌,男,1973年生,教授,博士生导师,Email: wangbin022800@126.com

王斌:男,1973年生,研究员,博士生导师,南京大学医学院附属鼓楼医院临床干细胞研究室负责人。2014~2016年在中国科学院遗传与发育生物学研究所担任副研究员,从事再生医学与神经损伤修复。长期从事临床干细胞建库与再生医学中枢神经损伤修复工作。担任中国老年学和老年医学学会老年病学分化干细胞专家委员会常务委员、中国研究型医院学会神经再生与修复专业委员会干细胞产业转化学组组长。在临床干细胞制备、质量检验、干细胞与再生医学修复中枢神经损伤等方面取得进展,以第一作者或者通讯作者在Nature Communications,Biomaterials等学术期刊发表SCI收录论著20余篇。
更新日期/Last Update: 2019-06-01