光交联丝素蛋白水凝胶的制备及生物医学应用-中国材料进展

文章信息/Info

Title:: Photocrosslinkable Silk Fibroin Hydrogels and Biomedical Application

Author(s):: LI Xiangming; WANG Zengkai; DONG Mingdong; LIU Lei; （Institute for Advanced Materials，School of Materials Science and Engineering，Jiangsu University，Zhenjiang 212013，China）

Keywords:: silk fibroin; photocrosslinkable; hydrogel; biomaterial; biomedical application

摘要:: 水凝胶是一类物理化学性质接近软组织的先进材料，已有众多聚合物用于水凝胶的制备。丝素蛋白由于具有优异的生物相容性、生物可降解性和易于制备成各种形式的材料等优点，在生物医学领域中具有广泛的应用，其中水凝胶是丝素蛋白在生物医学中应用的重要形式。由于分子的独特结构，丝素蛋白可以通过多种方法形成水凝胶。近年来，光交联水凝胶由于具有制备条件温和、副产物少、反应过程容易控制等优点，逐步成为研究的热点。首先对丝素蛋白的分子结构和特性进行了介绍，总结了丝素蛋白水凝胶的制备方法，重点阐述了光交联丝素蛋白水凝胶的研究现状，并讨论了它们在生物医学领域的应用，最后对光交联丝素蛋白水凝胶未来发展方向进行了展望。

Abstract:: Hydrogels are a kind of advanced materials with physical and chemical properties close to soft tissues. Many polymers have been used in the preparation of hydrogels. Silk fibroin has been widely used in biomedical application due to excellent biocompatibility, biodegradability and facility to fabricate into different types of materials. Hydrogel is an important form for silk fibroin in biomedical application and can be constructed by different approaches. Recently, the photocrosslinkable hydrogels have attracted enormous attention due to the impressive advantages such as mild preparation conditions, less by-product and excellent controllability. In this review, firstly, we present the molecular structure and characteristics of silk fibroin. Subsequently, the preparation methods of silk fibroin hydrogels are summarized. Furthermore, the preparation strategies of photocrosslinkable silk fibroin hydrogels are emphatically reviewed, and their applications in the biomedical field are discussed. Finally, the future research of the photocrosslinkable silk fibroin hydrogels is prospected.