响应性壳聚糖微球的研究-中国材料进展

文章信息/Info

Author(s):: ZHAO Tongyao; CHANG Linlin; WANG Lijuan; LIU Yajie; CAO Jincheng; GONG Yumei; (School of Textile and Material Engineering, Dalian Polytechnic University, Dalian 116034, China)

Keywords:: chitosan; microspheres; pH response; temperature response; magnetic response

摘要:: 随着绿色经济的发展，生物可降解的天然高分子引起了人们的兴趣，壳聚糖作为一种天然高分子材料，具有良好的生物相容性、生物可降解性、抗菌性、保湿性、成膜性等。近年来，利用壳聚糖微球作为载体并将其应用于药物的可控释放以及吸附等方面的研究受到了越来越多科学研究者的关注，尤其是在赋予壳聚糖响应性、实现其功能化等方面。综述了pH、温度、磁以及多重响应性壳聚糖微球的合成，总结了近几年响应性壳聚糖微球在水处理、靶向给药、药物缓释、固定化酶等方面的研究及应用，分析了响应性壳聚糖微球的优点以及存在的一些不足，并展望了响应性壳聚糖微球的未来发展方向。

Abstract:: With the development of green economy, biodegradable natural polymers have aroused people’s interest. As a natural polymer material, chitosan has the advantages of good biocompatibility, biodegradability, antibacterial，moisturizing, film-forming properties. In recent years, the use of chitosan microspheres as a carrier for the controlled release and adsorption of drugs has attracted more and more attention, especially in giving chitosan responsiveness and realizing its functionalization. Here, the synthesis of pH, temperature, magnetism and multiple responsive chitosan microspheres was reviewed, and the research and application of responsive chitosan microspheres in water treatment, targeted drug delivery, drug sustained release, immobilized enzymes, etc. in recent years were summarized. The advantages and disadvantages of responsive chitosan microspheres were analyzed, and the future development direction of responsive chitosan microspheres was prospected.