[1]李亚红,王剑,罗锋.ZIF-8递送生物大分子的研究进展[J].中国材料进展,2022,41(06):458-465.[doi:10.7502/j.issn.1674-3962.202010006]
 LI Yahong,WANG Jian,LUO Feng.Research Progress on Zeolitic Imidazolate Framework-8 for Biomacromolecules Delivery[J].MATERIALS CHINA,2022,41(06):458-465.[doi:10.7502/j.issn.1674-3962.202010006]
点击复制

ZIF-8递送生物大分子的研究进展()
分享到:

中国材料进展[ISSN:1674-3962/CN:61-1473/TG]

卷:
41
期数:
2022年第06期
页码:
458-465
栏目:
出版日期:
2022-06-30

文章信息/Info

Title:
Research Progress on Zeolitic Imidazolate Framework-8 for Biomacromolecules Delivery
文章编号:
1674-3962(2022)06-0458-08
作者:
李亚红王剑罗锋
(四川大学华西口腔医院,四川 成都 610041)
Author(s):
LI Yahong WANG Jian LUO Feng
(West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China)
关键词:
类沸石咪唑酯骨架-8(ZIF-8)药物递送生物大分子蛋白质核酸原位合成
Keywords:
zeolitic imidazolate framework-8 (ZIF-8) drug delivery biomacromolecule protein enzyme nucleic acid in-situ synthesis
分类号:
R318.08
DOI:
10.7502/j.issn.1674-3962.202010006
文献标志码:
A
摘要:
类沸石咪唑酯骨架-8(zeolitic imidazolate framework-8, ZIF-8)是一种由Zn2+和2-甲基咪唑组成的新型金属有机骨架材料,它具有孔隙率高、比表面积大、化学和热稳定性好、表面性质可调及pH诱导生物降解性等优点,这些优点赋予了ZIF-8多种功能,使其能广泛应用于气体吸附与分离、催化、药物传递等领域。近年来,研究人员通过原位合成的方法使ZIF-8可包封蛋白质、酶、核酸等生物大分子,生物大分子主要通过交联、键合与ZIF-8骨架结合,并包埋在ZIF-8晶体内部或位于其表面。ZIF-8作为运载体可递送蛋白质和酶以保持其生物学活性,提高其功能表现和稳定性;同时,ZIF-8亦可负载核酸药物使其在胞内表达用于基因治疗。综述了这些方面的研究进展和应用,并对ZIF-8在相关生物医学领域的应用进行了展望。
Abstract:
Zeolitic Imidazolate Framework-8 (ZIF-8), a novel metal-organic framework, is composed of zinc ions and 2-methylimidazole. It possesses advantages including high porosity, large specific surface area, good chemical and thermal stability, adjustable surface properties as well as pH-induced biodegradability. These advantages equip ZIF-8 with multiple functions, making it widely be used for gas adsorption and separation, catalysis, drug delivery and other fields. Recently, biomacromolecules such as proteins, enzymes and nucleic acids, can be encapsulated by ZIF-8 through in-situ synthesis to form composites. Biomacromolecules are embedded into ZIF-8 crystals or adhered to their surface through cross-linking and covalent bonding. ZIF-8 could serve as a carrier to deliver proteins and enzymes to maintain their biological activities, improving their functional performances and stability. Also, ZIF-8 could transmit nucleic acids, assisting them to express in cells for gene therapy. Therefore, this article reviews the recent research progress of ZIF-8 for biomacromolecules delivery on above issues, and prospects its application in related biomedical fields.

备注/Memo

备注/Memo:
收稿日期:2020-10-20 修回日期:2021-01-11 基金项目:四川大学华西口腔医院基础与应用基础研究项目(RD-02-201910)第一作者:李亚红,女,1997年生,硕士研究生 通讯作者:罗锋,男,1988年生,讲师,助理研究员, Email:luofeng0122@scu.edu.cn
更新日期/Last Update: 2022-05-26