[1]孙文瑾,李瑞珍,刘伟峰,等.基于碳量子点的分子印迹荧光检测体系研究进展[J].中国材料进展,2023,42(03):228-237.[doi:10.7502/j.issn.1674-3962.202106003]
　SUN Wenjin,LI Ruizhen,LIU Weifeng,et al.Research Progress of Molecularly Imprinted Fluorescence Detection System with Carbon Quantum Dots[J].MATERIALS CHINA,2023,42(03):228-237.[doi:10.7502/j.issn.1674-3962.202106003]
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基于碳量子点的分子印迹荧光检测体系研究进展()
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中国材料进展[ISSN:1674-3962/CN:61-1473/TG]

卷:
42
期数:
2023年第03期
页码:
228-237
栏目:
出版日期:
2023-03-30

文章信息/Info

Title:
Research Progress of Molecularly Imprinted Fluorescence Detection System with Carbon Quantum Dots
文章编号:
1674-3962(2023)03-0228-10
作者:
孙文瑾1; 2; 3; 李瑞珍1; 2; 3; 刘伟峰1; 2; 3; 刘旭光1; 2; 3
(1. 太原理工大学 新型碳材料研究院，山西 太原 030024) (2. 太原理工大学材料科学与工程学院，山西 太原 030024) (3. 新材料界面科学与工程教育部重点实验室，山西 太原 030024)
Author(s):
SUN Wenjin1; 2; 3; LI Ruizhen1; 2; 3; LIU Weifeng1; 2; 3; LIU Xuguang1; 2; 3
(1. Institute of New Carbon Materials, Taiyuan University of Technology, Taiyuan 030024, China) (2. School of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China) (3. Key Laboratory of Interface Science and Engineering in Advanced Materials, Ministry of Education, Taiyuan 030024, China)
关键词:
碳量子点; 分子印迹; 荧光检测; 构建策略; 工作机理
Keywords:
carbon quantum dots;  molecular imprinting;  fluorescence detection;  construction strategy;  working mechanism
分类号:
TB34;O657.3;TP212
DOI:
10.7502/j.issn.1674-3962.202106003
文献标志码:
A
摘要:
复杂基质中痕量分析物的高选择性和高灵敏度检测对环境保护和食品安全等问题具有重要意义。近年来，色谱法等传统检测方法可达到高灵敏度检测的需求，但在选择性、样品预处理过程、维护费用等方面不同程度地存在欠缺，因此迫切需要寻求一种兼具高灵敏度和高选择性，且成本低廉、简便快速的检测手段。将碳量子点（carbon quantum dots, CQDs）的荧光检测与分子印迹材料（molecularly imprinted polymers, MIPs）的分子识别耦合起来，构建高效的碳量子点分子印迹（CQDs-MIPs）荧光检测体系，合成路线简单、成本低廉，对目标物质的检测具有高灵敏度、高选择性和强的抗干扰能力，将会在复杂基质中极低浓度物质的检测方面发挥重要作用。MIPs具有与目标分子高度匹配的识别位点，可实现对目标分子的选择性识别和富集；CQDs作为一种新型的碳基纳米荧光材料，具有优异的光学特性、良好的水溶性和生物相容性，且绿色环保、无毒无害，对目标分子的高灵敏荧光响应使它在荧光检测领域具备不可替代的优势。综述了CQDs-MIPs检测体系的构建策略和工作机理，以及近年来在环境、食品和临床领域的应用进展，同时对其未来的发展方向进行了合理的预测。
Abstract:
The highly selective and sensitive detection of trace analytes in complicated matrix is of great significance to environmental protection and food safety. So far, traditional detection methods such as chromatography can realize high sensitivity detection. However, the detection processes suffer from some defects to some extent in selectivity, sample pretreatment process, and maintenance cost. Therefore, it is urgent to establish a simple and rapid detection method with high selectivity and high sensitivity. By coupling carbon quantum dots (CQDs) for fluorescence detection with molecularly imprinted polymers (MIPs) for molecular recognition, an efficient CQDs-based molecularly imprinted (CQDs-MIPs) fluorescence detection system is constructed. The system has facile synthesis route, low cost, high sensitivity, high selectivity, and strong anti-interference ability, and thus plays an important role in the detection of extremely low concentration analytes in complex matrix. MIPs can selectively recognize and enrich the target molecules owing to the recognition sites highly matching the target molecules. As one class of the new carbonbased fluorescent nanomaterials, CQDs are environment-friendly, non-toxic, harmless, and have excellent optical properties, good water solubility and biocompatibility, exhibiting irreplaceable advantages in the field of molecular detection based on their fluorescence response. This review mainly focuses on the construction strategies and sensing mechanism of CQDs-MIPs detection systems, and their application progresses in environmental, food and clinical fields in recent years. In addition, the future development of CQDs-MIPs is forecasted.

备注/Memo

备注/Memo:
收稿日期：2021-06-04修回日期：2021-08-31 基金项目：国家重点研发计划项目（2017YFB0603104）；国家自然 科学基金项目（U1610255，U1607120，51603142，21706170， 51902222，51972221）；山西省重点研发计划国际合作 项目（201903D421077）；山西省高等学校科技创新项目 （2019L0255） 第一作者：孙文瑾，女，1997年生，硕士研究生 通讯作者：刘旭光，男，1965年生，教授，博士生导师， Email:liuxuguang@tyut.edu.cn 刘伟峰，男，1986年生，副教授，硕士生导师， Email:lwf061586@yeah.net
更新日期/Last Update: 2023-02-27