[1]叶自强,毛峥伟.聚多巴胺基纳米材料的结构和抗氧化性能调控及其应用研究进展[J].中国材料进展,2022,41(09):679-688.[doi:10.7502/j.issn.1674-3962.202112029]
YE Ziqiang,MAO Zhengwei.Research Progress on the Regulation of Structure and Antioxidant Properties of Polydopamine-Based Nanomaterials and Their Biomedical Applications[J].MATERIALS CHINA,2022,41(09):679-688.[doi:10.7502/j.issn.1674-3962.202112029]
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聚多巴胺基纳米材料的结构和抗氧化性能调控及其应用研究进展()
中国材料进展[ISSN:1674-3962/CN:61-1473/TG]
- 卷:
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41
- 期数:
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2022年第09期
- 页码:
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679-688
- 栏目:
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- 出版日期:
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2022-09-30
文章信息/Info
- Title:
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Research Progress on the Regulation of Structure and Antioxidant Properties of Polydopamine-Based Nanomaterials and Their Biomedical Applications
- 文章编号:
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1674-3962(2022)09-0679-10
- 作者:
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叶自强1; 2; 毛峥伟1; 2
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(1. 教育部高分子合成与功能构造重点实验室,浙江 杭州 310027)(2. 浙江大学高分子科学与工程系,浙江 杭州 310027)
- Author(s):
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YE Ziqiang1; 2; MAO Zhengwei1; 2
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(1. Key Laboratory of Polymer Synthesis and Functional Structure, Ministry of Education, Hangzhou 310027, China) (2. Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China)
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- 关键词:
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聚多巴胺; 纳米材料; 生物材料; 抗氧化; 炎症治疗
- Keywords:
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polydopamine; nanomaterials; biomaterials; anti-oxidation; inflammation therapy
- 分类号:
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TQ460.4; R318.08
- DOI:
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10.7502/j.issn.1674-3962.202112029
- 文献标志码:
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A
- 摘要:
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聚多巴胺(polydopamine, PDA)作为典型的黑色素类似物,拥有优异的生物相容性和抗氧化活性,这些独特的特性使PDA基纳米材料在炎症治疗、创面修复、仿生材料制备等领域受到广泛关注。尽管相关研究已经取得了很大的进展,但是PDA基纳米材料的抗氧化机制目前尚不明确。总结和讨论了PDA基纳米材料近几年在抗氧化方面的重要研究进展。在第一部分,简要介绍了PDA基纳米材料的合成及其抗氧化机制研究进展。在第二部分,主要从粒径、微观结构和氧化还原程度3个方面对其抗氧化性能的调控进行了总结。在第三部分,总结了PDA基纳米材料的抗氧化性能在生物医学领域的应用。最后,讨论了PDA基纳米材料面临的挑战及未来发展前景。希望能为基于PDA的抗氧化功能的材料的设计和开发提供思路与参考。
- Abstract:
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Polydopamine (PDA), as the most typical melanin analog, possesses excellent antioxidant activity and biocompatibility. These unique properties make PDA-based nanomaterials widely concerned in the fields of inflammation treatment, wound repair and biomimetic material preparation. Although great progress has been made, the antioxidant mechanism of PDA-based nanomaterials remains unclear. In this review, we summarize and discuss the important research progress of PDA-based nanomaterials in anti-oxidation in recent years. In the first section, we introduce the synthesis and antioxidant mechanism of PDA-based nanomaterials. In the second section, we summarize the regulation of its antioxidant properties mainly from three aspects: particle size, microstructure and redox degree. In the third section, we summarize the antioxidant properties of PDA-based nanomaterials for biomedical applications. Finally, we discuss the challenges and future development prospects of PDA-based nanomaterials. We hope that this review can provide ideas and references for the design and development of PDA-based nanomaterials with antioxidant functions.
备注/Memo
- 备注/Memo:
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收稿日期:2021-12-31 修回日期:2022-05-11 基金项目:国家自然科学基金项目(51822306)第一作者:叶自强,男,1997年生,硕士研究生通讯作者:毛峥伟,男,1980年生,教授,博士生导师, Email: zwmao@zju.edu.cn
更新日期/Last Update:
2022-08-22