[1]何明玥,昌依凌,易曼,等.基于抗氧化功能的纳米材料在辐射防护中的研究进展[J].中国材料进展,2026,45(01):037-48.[doi:10.7502/j.issn.1674-3962.202411024]
　HE Mingyue,CHANG Yiling,YI Man,et al.Research Progress of Nanomaterials Based on Antioxidant Function in Radiation Protection[J].MATERIALS CHINA,2026,45(01):037-48.[doi:10.7502/j.issn.1674-3962.202411024]
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基于抗氧化功能的纳米材料在辐射防护中的研究进展()

中国材料进展[ISSN:1674-3962/CN:61-1473/TG]

卷:
45
期数:
2026年01
页码:
037-48
栏目:
出版日期:
2026-01-31

文章信息/Info

Title:
Research Progress of Nanomaterials Based on Antioxidant Function in Radiation Protection
文章编号:
1674-3962(2026)01-0037-12
作者:
何明玥; 昌依凌; 易曼; 高妙; 欧舒斐; 李基根
中国人民解放军火箭军广州特勤疗养中心 医学影像科，广东 广州 510000
Author(s):
HE Mingyue;  CHANG Yiling;  YI Man;  GAO Miao;  OU Shufei;  LI Jigen
Department of Medical imaging, Guangzhou Special Service Recuperation Center of PLA Rocket Force,Guangzhou 510000, China
关键词:
辐射防护; 放射治疗; 抗氧化; 类酶活性; 纳米酶
Keywords:
adiation protection;  radiotherapy;  anti-oxidation;  enzyme-like activity;  nano-enzyme
分类号:
TB34；R318.08
DOI:
10.7502/j.issn.1674-3962.202411024
文献标志码:
A
摘要:
放射治疗（简称放疗）是治疗肿瘤性相关疾病的有效方法。然而，高频率的放疗容易诱发多种放射性炎性疾病，造成周围正常组织的损伤。因此，减轻辐射导致的多种副作用对提高放疗效果至关重要。辐射诱导过量活性氧生成，进而蓄积于组织器官内形成炎性环境，引发细胞凋亡，导致多种组织器官损伤。清除自由基以抵抗人体器官过度氧化是现有电离辐射防护手段的主流途径。然而，传统的电离辐射防护剂因稳定性差、副作用多、制作成本高及体内循环过快等缺陷，制约了其辐射防护功能的发展。为此，研究者们开发了大量具有纳米酶功能的生物材料用于解决放疗副作用，其中纳米材料的类酶活性开辟了辐射防护新途径，提升了辐射防护剂的稳定性及可持续生物活性。总结了近年来具有抗氧化功能的纳米材料在不同组织器官中辐射防护的最新进展，旨在为预防放疗副作用及治疗放疗诱导的相关疾病提供新的思路。此外，进一步讨论了现有纳米材料在辐射防护领域的发展前景及挑战。
Abstract:
Radiotherapy is an efficacious method for treating tumor-related diseases. However, high-frequency radiotherapy can readily result in a spectrum of radiation-induced inflammatory conditions, leading to damage to surrounding normal tissues. It is therefore important to reduce the side effects of radiation and improve the radiotherapy effect. Ionizing radiation induces the generation of excessive reactive oxygen species, which accumulate in tissues and organs to form an inflammatory environment, trigger cell apoptosis and lead to a variety of tissue and organ damage. The principal method of radioprotection is the removal of reactive oxygen species in order to resist the excessive oxidation of human organs. However, the traditional radioprotective agent has numerous shortcomings, including instability, a multitude of adverse effects, a high production cost and rapid circulation in the body, which collectively impede the advancement of its radiation protection capabilities. In light of these considerations, researchers have developed a plethora of biomaterials with nano-enzyme functionalities to mitigate the adverse effects of radiotherapy. Among these, the enzyme-like activity of nanomaterials represents a novel avenue for radiation protection, offering enhanced stability and sustained biological activity for radiation protection agents. This paper presents a summary of the recent progress in the development of antioxidation nanomaterials for the purpose of radiation protection in different tissues and organs. The aim of this paper is to provide new ideas for the prevention of radiotherapy side effects and the treatment of radiationinduced related diseases. In addition, the development prospects and challenges of existing nanomaterials in radiation protection are discussed.

备注/Memo

备注/Memo:
收稿日期：2024-11-26修回日期：2025-01-14 第一作者：何明玥，女，1993年生，主治医师 通讯作者：李基根，男，1973年生，副主任医师， Email: lijigen0904@163.com
更新日期/Last Update: 2025-12-29