[1]杨柯,任玲.新型含铜金属心血管支架材料[J].中国材料进展,2018,(07):006-10.
 YANG Ke,REN Ling.Novel Cu-bearing Metal Coronary Stent Materials[J].MATERIALS CHINA,2018,(07):006-10.
点击复制

新型含铜金属心血管支架材料()
分享到:

中国材料进展[ISSN:1674-3962/CN:61-1473/TG]

卷:
期数:
2018年第07期
页码:
006-10
栏目:
前沿综述
出版日期:
2018-07-31

文章信息/Info

Title:
Novel Cu-bearing Metal Coronary Stent Materials
作者:
杨柯任玲
(中国科学院金属研究所,辽宁 沈阳 110016)
Author(s):
YANG KeREN Ling
(Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China)
关键词:
含铜金属心血管支架生物功能支架内再狭窄
Keywords:
Cu-bearing metalcoronary stentbiofunctionin-stent restenosis
文献标志码:
A
摘要:
铜(Cu)作为人体内不可缺少的微量金属元素,其不仅对维持人体健康起着多方面的重要作用,同时还对心血管系统的健康至关重要。针对支架内再狭窄(ISR)问题,中国科学院金属研究所杨柯团队利用Cu元素对心血管系统的有益生物功能,以现有心血管支架材料(不锈钢、钴基合金)为基础,创新地发展出具有生物功能的新型含铜血管支架材料(含铜不锈钢、含铜钴基合金)。本文综述了近年来团队在新型含铜金属血管支架材料方面的研究进展,包括体外和动物体内实验研究结果,包括其促进血管内皮化、抑制动脉平滑肌增殖与迁移、抑制血栓等多重生物功能。研究结果表明,含铜金属血管支架材料促进内皮细胞增殖及迁移,并降低其凋亡率;对动脉平滑肌增殖及迁移具有抑制作用,并促进其凋亡;减少血小板在其表面的粘附,延长动态凝血时间,进而降低血栓形成倾向。此外,新型含铜金属血管支架材料还具有有优异的生物相容性。动物实验结果表明,含铜不锈钢心血管支架在体内可明显促进内皮化,抑制血栓形成,并具有优异的生物相容性,进而抑制ISR的发生。新型含铜金属材料有望成为具有降低ISR功能的新一代心血管支架材料而得到临床应用。
Abstract:
 Copper (Cu), as an indispensable trace metal element in the human body, plays an important role not only in the maintenance of human health, but also for the health of the cardiovascular system. In view of the problem of in-stent restenosis (ISR) in clinic, the team led by Prof. Ke Yang in the Institute of Metal Research, Chinese Academy of Sciences, based on the currently used coronary stent materials (316L stainless steel and L605 cobalt based alloy), has developed a new class of Cu-bearing metal materials for stent application (316L-Cu stainless steel and L605-Cu cobalt based alloy). This paper reviews the recent advances in the research team regarding this new class of Cu-bearing metal stent materials, and their effects on cardiovascular system from in vitro and in vivo studies, including promotion of vascular endothelialization, inhibition of arterial smooth muscle proliferation and migration, and inhibition of thrombus. The experimental results showed that these Cu-bearing metal stent materials promoted the proliferation and migration of endothelial cells and reduced the apoptosis rate, inhibited the proliferation and migration of arterial smooth muscle and promoted its apoptosis, reduced the adhesion of platelets on the metal surface, prolonged the dynamic coagulation time, and thus reduced the tendency of thrombosis. In addition to these, the new stent materials also have excellent biocompatibility. The in vivo studies showed that implantation of the Cu-bearing stainless steel stent in animals could obviously promote endothelialization, inhibit thrombosis, have excellent biocompatibility, and then inhibit the occurrence of ISR. Consequently, these new Cu-bearing metal materials are expected to be a new generation coronary stent materials with function of reducing occurrence of ISR.
更新日期/Last Update: 2018-06-28