MOFs衍生纳米酶在肿瘤治疗中的研究进展-中国材料进展

文章信息/Info

Author(s):: QIN Liting; SUN Yun; XU Bolong; LIU Huiyu; （Key Laboratory of OrganicInorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China）

Keywords:: metal organic framework; nanozyme; activity regulation; catalytic therapy; tumor therapy

摘要:: 纳米酶是具有类酶活性的纳米材料，与天然酶相比，纳米酶具有易于合成、活性可调和高稳定性的优势。金属有机框架（metal-organic frameworks，MOFs）衍生纳米酶作为纳米酶家族的新成员，因其丰富的活性位点和可控的催化活性，吸引了研究者的广泛关注。与传统纳米酶相比，MOFs衍生纳米酶保留了MOFs的多孔结构，同时表现出良好的生物相容性和高催化活性，在包括肿瘤催化治疗在内的生物医学应用中展现出广阔的前景。系统地总结了MOFs衍生纳米酶的种类，包括MOFs衍生的金属氧化物、金属/碳、金属氧化物/碳、金属硫化物以及单原子纳米酶。此外，重点讨论了MOFs衍生纳米酶的活性调控策略，如表面结构调控、杂原子掺杂、双金属构建和基于MOFs的配体交换策略。同时，回顾了近年来MOFs衍生纳米酶介导的催化治疗及其联合其他疗法在抗肿瘤领域的应用。最后，总结了MOFs衍生纳米酶目前在生物医学领域中面临的挑战和前景，以期推动MOFs衍生纳米酶的开发并拓展其进一步的生物医学应用转化。

Abstract:: Nanozymes are a class of nanomaterials with enzyme-like activity. Compared with natural enzymes, nanozymes have the advantages of easy synthesis, adjustable activity, and high stability. The nanozymes derived from the metal-organic frameworks (MOFs), as a new family member of nanozymes, have attracted widespread attention due to their rich active sites and controllable catalytic activity. Compared with the traditional nanozymes, MOFs-derived nanozymes maintain the porous structure of MOFs, as well as possess good biocompatibility and high catalytic activity, showing a broad prospect in the biomedical field including tumor catalytic therapy. In this review, we systematically summarize the classification of MOFs-derived nanozymes, including MOFs-derived metal oxides, metal/carbon, metal oxides/carbon, metal sulfide, and single-atom nanozymes (SAzymes). In addition, we also focus on the activity regulation strategies of MOFs-derived nanozymes, such as surface structure regulation, heteroatomic doping, bimetallic construction, and MOFs-based linker exchange strategy. Furthermore, we review the applications of catalytic therapies based on MOFs-derived nanozymes and their synergistic therapies in recent years. Finally, we propose the challenges and prospects of MOFs-derived nanozymes in the biomedical field, to promote the development of MOFs-derived nanozymes and expand their further biomedical application transformation.