无机声敏剂在肿瘤声动力治疗中的研究进展-中国材料进展

文章信息/Info

Title:: Progress in the application of inorganic sonosensitizers in tumor sonodynamic therapy

作者:: 杨亚丽; 聂继虎; 杨乃霖; 孙淑敏; 程亮; 1.苏州大学分析测试中心，江苏苏州,215123 2苏州大学功能纳米与软物质研究院, 江苏苏州 215123

Author(s):: Yali Yang; Jihu Nie; Nailin Yang; Shumin Sun; Liang Cheng; 1.Analytical and Testing Center, Soochow University, Suzhou 215123, Jiangsu, China 2.Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123, Jiangsu, China

Keywords:: Sonodynamic therapy; inorganic sonosensitizers; electron hole pairs; tumor microenvironment; immunotherapy

摘要:: 声动力治疗（SDT）作为一种新兴的非侵入性肿瘤治疗技术，通过超声激发声敏剂产生活性氧（ROS）来杀伤癌细胞，因其优异的组织穿透性、高效治疗效应和低毒副作用而备受关注。近年来开发高效低毒声敏剂已成为该领域的研究热点。无机声敏剂由于具有优异的稳定性、可控的理化性质、多功能整合能力及肿瘤靶向性，在SDT领域展现出巨大潜力。本文系统总结了无机声敏剂的演进历程，将其划分为三代：第一代通过优化材料结构提升性能，第二代聚焦肿瘤微环境调控以增强SDT疗效，第三代则通过调节免疫反应实现协同治疗。最后，本文探讨了当前无机声敏剂面临的挑战并展望了未来发展方向。

Abstract:: As an emerging non-invasive tumor treatment technique, sonodynamic therapy (SDT) uses ultrasound to stimulate sonosensitizers to generate reactive oxygen species (ROS) to kill cancer cells. It has attracted much attention due to its excellent tissue penetration, efficient therapeutic effect, and low toxicity. In recent years, the development of efficient and low toxicity sound sensitizers has become a research hotspot in this field. Inorganic sonosensitizers have shown great potential in the field of SDT due to their excellent stability,controllable physicochemical properties, multifunctional integration ability, and tumor targeting ability. This review systematically summarizes the evolution of inorganic sound sensitizers and divides them into three generations: the first generation improves performance by optimizing material structure; the second generation focuses on regulating the tumor microenvironment to enhance SDT efficacy; and the third generation achieves synergistic therapy by regulating immune response. Finally, this artivle discusses the challenges currently faced by inorganic sonosensitizers and looks forward to future development directions.