[1]石强,栾世方,金晶,等.通用高分子材料的化学和生物改性及其血液相容性研究[J].中国材料进展,2014,(4):212-223.[doi:10.7502/j.issn.1674-3962.2014.04.03]
　SHI Qiang,LUAN Shifang,JIN Jing,et al.Hemocompatibility of Commodity Polymers Modified with Chemical and Biological Method[J].MATERIALS CHINA,2014,(4):212-223.[doi:10.7502/j.issn.1674-3962.2014.04.03]
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通用高分子材料的化学和生物改性及其血液相容性研究()
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中国材料进展[ISSN:1674-3962/CN:61-1473/TG]

卷:
期数:
2014年第4期
页码:
212-223
栏目:
特约研究论文
出版日期:
2014-04-30

文章信息/Info

Title:
Hemocompatibility of Commodity Polymers Modified with Chemical and Biological Method
作者:
石强; 栾世方; 金晶; 石恒冲; 殷敬华; 李勇刚
中国科学院长春应用化学研究所 高分子物理与化学国家重要实验室， 长春，130022
威高集团有限公司，威海，264209
Author(s):
SHI Qiang; LUAN Shifang; JIN Jing; SHI Hengchong;  YIN Jinghua*
?State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China
关键词:
通用高分子; 化学和生物改性; 血液相容性
DOI:
10.7502/j.issn.1674-3962.2014.04.03
文献标志码:
A
摘要:
功能化与高性能化的通用高分子材料在医用耗材及器械领域有着广泛的应用。作为重要的医用材料之一，血液相容性是首先需要解决的关键科学问题。通用高分子的血液相容性可通过化学和生物修饰来实现。采用的方法大体分为本体改性和表面改性。本体改性主要通过反应接枝和反应共混实现；而表面改性则主要通过在材料表面（1）制备亲水性聚合物刷或亲水层，(2) 固定生物活性分子和（3）形成生物仿生膜来实现。目前，生物材料的血液相容性研究主要集中在血浆蛋白吸附、血小板黏附和红细胞溶血三个方面。本文结合本课题组近期在生物医用材料领域的研究成果，简要介绍了国内外近年来通用高分子材料的化学和生物改性及其血液相容性研究进展。
Abstract:
Commodity polymers with high functionality and performance are widely applied in the field of biomedical supplies and equipment. As one of most important biomaterials, hemocompatibility is a key challenge. The hemocompatibility of commodity polymers can be improved with chemical and biological method, including bulk and surface modification in general. Bulk modification was obtained by melt grafting and blending, while surface modification could be achieved through (i) surface passivation with hydrophilic layers, (ii) immobilization of bioactive molecules and (iii) formation of biomimetic membrane. The investigation of hemocompatibility was mainly concentrated on plasma protein adsorption, platelet adhesion and hemolysis of red blood cell. This report presents an overview on hemocompatibility of modified commodity polymers, with focus on the progress achieved by our research group in Changchun Institute of Applied Chemistry in recent years.
更新日期/Last Update: 2014-03-26