(1.Key Laboratory of Interface Science and Engineering in Advanced Materials of Ministry of Education,Taiyuan University of Technology, Taiyuan 030024, China)(2.College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China)(3.Research Center on Advanced Materials Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China)(4.College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China)
The controlled release behavior of targeted drug delivery has attracted widespread concern. In this paper, magnetic targeted drug carrier (HMOMCNs), which can covalently bond to anti-cancer drug doxorubicin hydrochloride (DOX), was synthesized from ordered mesoporous carbon nanospheres (OMCNs) through magnetization, amination and hydrazine modification. The structural characterization and performance evaluation of HMOMCNs were carried out by field emission scanning electron microscopy, X-ray diffraction analyzer, thermogravimetric analyzer, Fourier transformation infrared spectroscopy and ultraviolet-visible spectrophotometer. The results showed that the HMOMCNs had a particle size of about 100 nm with good ordered mesoporous structure, and the maximum drug loading capacity was 529.18 mg·g-1. The release of DOX from HMONCNs can be controlled by pH values. With the decrease of the pH value, the cumulative release rate increased. When pH was 5.5, the cumulative release rate was 76% and reached the equilibrium for about 10 h.