1. School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
2. Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China
3. School of Materials Science and Engineering, East China University of Science and Technology,Shanghai 200237, China
4. East China University of Science and Technology Shenzhen Research Institute, Shenzhen 518063, China
A series of poly(N,N-dimethyl-2-oxazoline) with different degrees of polymerization were designed and synthesized. The polymers were quaternized with alkyl bromide of different chain lengths. The minimum inhibitory concentration, minimum bactericidal concentration against Staphylococcus epidermis and hemolysis test of the quaternized polymers were conducted. The results showed that the polymers have good antibacterial activity against Staphylococcus epidermis, and low hemolysis of the quaternized polymers to erythrocytes, showing its good selectivity and promising biomedical application. Moreover, the antibacterial activity of the polymers to multidrug-resistant strain is better than that of standard strain, which shows the potential of this kind of polymers in treating multidrug-resistant bacterial infection.