无机-有机复合组织器官工程材料的微纳制造-中国材料进展

文章信息/Info

Title:: Micro/Nano Fabrication of Inorganic/Organic Composite Scaffold for Tissue Engineering

Author(s):: QIU Zhiye; WANG Jianglin; ZHOU Jiaojiao; ZHANG Shengmin; (Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan 430074, China)

摘要:: 无机-有机复合组织器官工程支架的微纳制造是近年来兴起的生物材料研究领域，相对传统的生物材料与组织工程材料制造技术，微纳制造整合了微纳米技术、计算机辅助设计、数字化制造等先进技术手段，为新型生物医用材料的开发以及生物材料制造新技术、新设备的研发提供了新的技术路线。综述了生物医用材料、特别是组织器官工程与组织修复材料微纳制造技术现状及发展趋势，主要内容包括生物材料的微纳米化及实现途径、组织器官工程支架材料的数字化设计、组织器官工程支架材料的数字化制造新技术等，对我国组织器官工程（修复）材料数字化微纳制造新技术的优先发展领域提出了展望。

Abstract:: Micro/nano fabrication of inorganic/organic composite scaffold for tissue engineering is a biomaterial research field arisen in recent years. Compared to conventional fabrication technique for biomaterials and tissue engineering materials, micro/nano fabrication, which has been integrated with advanced techniques such as micron/nano technology, computer aided design and digital manufacturing, provides new technical routes for the development of novel biomedical materials. Current situation and developing trends of biomedical materials, especially micro/nano fabrication technique of tissue engineering and tissue repair materials, are reviewed, mainly including realizations and approaches of micro/nanosize biomaterials, digital design of tissue engineering scaffolds, as well as new techniques for digital manufacturing of tissue engineering scaffolds. Moreover, a strategic outlook is proposed for priority areas for development in new techniques of digital micro/nano fabrication of tissue engineering (repair) materials in China.