仿生功能化骨修复材料研究-中国材料进展

文章信息/Info

作者:: 杜昶; 赵娜如; 叶建东; 陈晓峰; 王迎军; (1.华南理工大学材料科学与工程学院，广东广州 510640)
（2.华南理工大学国家人体组织功能重建工程研究中心，广东广州 510006)

Author(s):: DU Chang; ZHAO Naru; YE Jiandong; CHEN Xiaofeng; WANG Yingjun; (1.School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China）
(2.National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China）

摘要:: 由肿瘤、炎症及各类创伤而导致的骨组织坏死、病变、缺失及骨折是临床多发病症，自体骨移植虽然是临床治疗的“金标准”，但由于供体受限而很难满足需求。通过对天然骨本身的成分、结构特性及矿化过程的模仿，应用先进材料制备技术，特别是纳米技术，对材料的组成、结构进行设计与调控，获得仿生型骨修复材料或者对传统材料进行仿生功能化修饰，以满足临床对病损或缺失的骨组织进行有效修复和功能重建具有重要意义。阐述了仿生功能化骨修复材料的相关研究，主要包括类骨钙磷纳米矿物的合成，有机分子模板对纳米矿物尺寸和形貌的调控，以及仿生多孔结构支架的构建等。

Abstract:: Bone defect and bone fracture are common clinical implications due to bone tumor resection, bone necrosis, osteitis and various traumas. Transplantation of autograft that comes from a healthy site in patient to the defect site is the gold standard treatment but the donor shortage limits its application. Mimicking the compositional and structural characteristics of bone and its biomineralization process, biomimetic functionalized bone repair materials can be produced with advanced materials synthesis and processing techniques, in particular nanotechnology development to a precise modulation. This manuscript focuses on the synthesis of nanoscale calcium and phosphate containing minerals, the control of organic molecular templates on the size and morphology of bone like minerals, as well as the construction of biomimetic porous scaffold.