[1]钱思昊,潘齐超,张亚琼,等.抗蛋白/细胞粘附的两性离子功能化聚对二甲苯薄膜[J].中国材料进展,2023,42(07):559-565.[doi:10.7502/j.issn.1674-3962.202210017]
　QIAN Sihao,PAN Qichao,ZHANG Yaqiong,et al.Zwitterions Functionalized Parylene for Protein/Cell Repulsion[J].MATERIALS CHINA,2023,42(07):559-565.[doi:10.7502/j.issn.1674-3962.202210017]
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抗蛋白/细胞粘附的两性离子功能化聚对二甲苯薄膜()
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中国材料进展[ISSN:1674-3962/CN:61-1473/TG]

卷:
42
期数:
2023年第07期
页码:
559-565
栏目:
出版日期:
2023-07-31

文章信息/Info

Title:
Zwitterions Functionalized Parylene for Protein/Cell Repulsion
文章编号:
1674-3962(2023)07-0559-07
作者:
钱思昊1; 2; 潘齐超1; 2; 张亚琼1; 2; 何勇1; 朱波2
1.东华大学材料科学与工程学院 纤维材料改性国家重点实验室，上海 201620 2.上海大学材料科学与工程学院，上海 200444
Author(s):
QIAN Sihao1; 2;  PAN Qichao1; 2;  ZHANG Yaqiong1; 2;  HE Yong1;  ZHU Bo2
1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China 2. School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China
关键词:
聚对二甲苯; 两性离子; 磷酸胆碱; 抗非特异性粘附; 图案化
Keywords:
parylene;  zwitterion;  phosphorylcholine;  antifouling;  pattern
分类号:
O632.7+1
DOI:
10.7502/j.issn.1674-3962.202210017
文献标志码:
A
摘要:
目前生物电子器件材料在复杂的生物环境中容易粘附蛋白/细胞等，进而影响器件的长期稳定性。研究并制备了抗非特异性蛋白/细胞粘附的两性离子功能化聚对二甲苯薄膜材料。通过原子转移自由基聚合方法在具有溴引发剂的聚对二甲苯表面接枝两性离子基团得到该薄膜材料。探索了不同两性离子聚合物分子链——聚甲基丙烯酸甲酯磷酸胆碱（PMPC）、聚甲基丙烯酸甲酯磺酸甜菜碱（PMSB）、聚甲基丙烯酸甲酯羧酸甜菜碱（PMCB）修饰的聚对二甲苯抗蛋白和细胞粘附的能力，发现PMPC修饰的聚对二甲苯性能最为优异。此外，采用光刻技术制备了PMPC修饰的聚对二甲苯图案化的生物界面，实现了在空间上控制细胞粘附行为。为聚对二甲苯薄膜的表面抗炎症细胞粘附及控制神经细胞生长提供了可能性，在生物电子器件领域具有潜在的应用价值。
Abstract:
Biomaterials for bioelectronics are susceptible to the adhesion of proteins/cells, which will affect the chronic stability of devices. Here, Anti-fouling parylene films were studied and prepared to resist the adhesion of proteins or cells. Bromine functionalized parylene film was first deposited on parylene, and then, atom transfer radical polymerization was conducted to modify parylene with zwitterions. Three different types of zwitterionic polymers, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), poly(2-methacryloyloxyethyl sulfobetaine) (PMSB) and poly(2-methacryloyloxyethyl carboxybetaine) (PMCB) were used to modify parylene, and their properties were studied. It was observed that PMPC-functionalized parylene showed the best antifouling properties. Moreover, the PMPC-functionalized parylene was also utilized to fabricate patterned bio-platform by a lithography-combined microfabrication for spatially guiding neural cell attachment. These zwitterionic functionalized parylene films, which can resist anti-inflammatory cells and control the growth of nerve cells, have a promising future in the field of bioelectronic devices.

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备注/Memo

备注/Memo:
收稿日期：2022-10-14修回日期：2023-02-17 基金项目：国家自然科学基金资助项目（22175111，21474014） 第一作者：钱思昊，女，1991年生，博士研究生 通讯作者：朱波，男，1971年生，教授，博士生导师， Email:bozhu@shu.edu.cn
更新日期/Last Update: 2023-07-03